Document Detail

Dual Window Dual Bandwidth Spectroscopic Optical Coherence Tomography Metric for Qualitative Scatterer Size Differentiation in Tissues.
MedLine Citation:
PMID:  22692864     Owner:  NLM     Status:  Publisher    
This work investigates the autocorrelation bandwidths of dual window (DW) optical coherence tomography (OCT) k-space scattering profile of different-sized microspheres and their correlation to scatterer size. A dual bandwidth (DB) spectroscopic metric defined as the ratio of the 10% to 90% autocorrelation bandwidths is found to change monotonically with microsphere size and gives the best contrast enhancement for scatterer size differentiation in the resulting spectroscopic image. A simulation model supports the experimental results and revealed a trade-off between the smallest detectable scatterer size and the maximum scatterer size in the linear range of the DWDB metric, which depends on the choice of the light source optical bandwidth. Spectroscopic OCT (SOCT) images of microspheres and tonsil tissue samples based on the proposed DWDB metric showed clear differentiation between different-sized scatterers as compared to those derived from conventional short-time Fourier transform (STFT) metrics. The DWDB metric significantly improves the contrast in SOCT imaging and can aid the visualization and identification of dissimilar scatterer size in a sample. Potential applications include the early detection of cell nuclear changes in tissue carcinogenesis, the monitoring of healing tendons and cell proliferation in tissue scaffolds.
B C M Tay; T H Chow; B K Ng; T K S Loh
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-6-04
Journal Detail:
Title:  IEEE transactions on bio-medical engineering     Volume:  -     ISSN:  1558-2531     ISO Abbreviation:  -     Publication Date:  2012 Jun 
Date Detail:
Created Date:  2012-6-13     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0012737     Medline TA:  IEEE Trans Biomed Eng     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
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