Document Detail

Dual-Time-Point FDG PET/CT for the Evaluation of Pediatric Tumors.
MedLine Citation:
PMID:  23345365     Owner:  NLM     Status:  In-Data-Review    
OBJECTIVE: The utility of dual-time-point (18)F-FDG PET/CT in differentiating benign from malignant processes in pediatric patients was assessed.
SUBJECTS AND METHODS: Twenty-one patients (13 girls and eight boys; age range, 1-17 years) with suspected malignancy underwent dual-time-point FDG PET/CT. Scan 1 was performed at approximately 60 minutes after IV injection of 5.18 MBq/kg of FDG, and scan 2 was performed at 121 ± 43 minutes after the first scan. Regions of interest were overlaid onto each non-attenuated-corrected image, and semiquantitative analysis was performed using the standardized uptake value (SUV) obtained from early and delayed images. A retention index was calculated according to the following equation: [(delayed SUV - early SUV) / early SUV] × 100. Results were compared prospectively in relation to pathologic examination or other conventional radiologic imaging or clinical follow-up. A retention index of 10% or higher was chosen as a cutoff for differentiating malignant from benign entities.
RESULTS: For patients with malignant disease, the average SUV increased from 7.3 ± 1.2 to 10.9 ± 2.7 between the two time points, whereas the SUV changed from 4.5 ± 0.8 to 4.2 ± 1.0 for patients with benign lesions. The average retention index was 37.1% ± 10.8% for patients with malignant lesions versus -9.9% ± 7.1% for benign lesions (p < 0.01). With a cutoff value of 10% or higher for the retention index, the sensitivity and specificity of dual-time-point FDG PET/CT were 77% and 80%, respectively.
CONCLUSION: These data show that dual-time-point FDG PET/CT is useful in distinguishing malignant from benign processes in pediatric patients.
Danny L Costantini; Reza Vali; Jeffery Chan; Susan McQuattie; Martin Charron
Related Documents :
7209575 - Ten section approach to computed tomography of the pelvis.
23577035 - Optimal labeling dose, labeling time, and magnetic resonance imaging detection limits o...
1718125 - A modified method for the detection of nucleolar organizer regions (agnors).
3535605 - Standard and computed tomography in the evaluation of neoplasms of the chest. a compara...
21992905 - Dysmyelination of the cerebral white matter with microdeletion at 6p25.
9932685 - Predicting the need for thoracoscopic evacuation of residual traumatic hemothorax: ches...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  AJR. American journal of roentgenology     Volume:  200     ISSN:  1546-3141     ISO Abbreviation:  AJR Am J Roentgenol     Publication Date:  2013 Feb 
Date Detail:
Created Date:  2013-01-24     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7708173     Medline TA:  AJR Am J Roentgenol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  408-13     Citation Subset:  AIM; IM    
Faculty of Medicine, University of Toronto, Toronto, ON, Canada.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Intracranial hypotension: improved MRI detection with diagnostic intracranial angles.
Next Document:  Vascular anomalies: hemangiomas and beyond--part 1, Fast-flow lesions.