Document Detail

Dual roles of dopamine in food and drug seeking: the drive-reward paradox.
MedLine Citation:
PMID:  23044182     Owner:  NLM     Status:  MEDLINE    
The question of whether (or to what degree) obesity reflects addiction to high-energy foods often narrows to the question of whether the overeating of these foods causes the same long-term neuroadaptations as are identified with the late stages of addiction. Of equal or perhaps greater interest is the question of whether common brain mechanisms mediate the acquisition and development of eating and drug-taking habits. The earliest evidence on this question is rooted in early studies of brain stimulation reward. Lateral hypothalamic electrical stimulation can be reinforcing in some conditions and can motivate feeding in others. That stimulation of the same brain region should be both reinforcing and drive inducing is paradoxical; why should an animal work to induce a drive-like state such as hunger? This is known as the drive-reward paradox. Insights into the substrates of the drive-reward paradox suggest an answer to the controversial question of whether the dopamine system--a system downstream from the stimulated fibers of the lateral hypothalamus--is more critically involved in wanting or in liking of various rewards including food and addictive drugs. That the same brain circuitry is implicated in the motivation for and the reinforcement by both food and addictive drugs extends the argument for a common mechanism underlying compulsive overeating and compulsive drug taking.
Roy A Wise
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Intramural; Review     Date:  2012-10-05
Journal Detail:
Title:  Biological psychiatry     Volume:  73     ISSN:  1873-2402     ISO Abbreviation:  Biol. Psychiatry     Publication Date:  2013 May 
Date Detail:
Created Date:  2013-04-16     Completed Date:  2013-10-21     Revised Date:  2014-05-08    
Medline Journal Info:
Nlm Unique ID:  0213264     Medline TA:  Biol Psychiatry     Country:  United States    
Other Details:
Languages:  eng     Pagination:  819-26     Citation Subset:  IM    
Copyright Information:
Published by Elsevier Inc.
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MeSH Terms
Behavior, Addictive / physiopathology*
Brain / physiopathology*
Dopamine / physiology*
Drug-Seeking Behavior / physiology*
Feeding Behavior / physiology*
Grant Support
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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