| A Dual Radiologic Contrast Agent Protocol for (18)F-FDG and (18)F-FLT PET/CT Imaging of Mice Bearing Abdominal Tumors. | |
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MedLine Citation:
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PMID: 20632117 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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PURPOSE: The aim of the study was to improve abdominal tumor detection by use of a dual radiologic contrast protocol. PROCEDURES: eXia160® (Benitio international) was mixed with 2-deoxy-2-[(18)F]fluoro-D: -glucose or 3'-[(18)F]fluoro-3'-deoxythymidine for intravenous (IV) injections. Omnipaque® 300 (GE healthcare) was used for intraperitoneal (IP) injections. Positron emission tomography/computed tomography (PET/CT) scans were acquired on a Siemens Biograph® equipped with point spread function reconstruction. The optimal concentration and injection schedule of IP contrast agent was studied in 12 mice. The impact of IP contrast media on PET quantitative accuracy was investigated by phantom studies and by imaging six mice before and after IP injection of Omnipaque®. The impact of a dual contrast media protocol on tumor delineation and quantitation was evaluated in 15 tumor-bearing mice using ex vivo counting as the reference. RESULTS: The optimal sequence was a mixture of tracer plus IV contrast agent followed by 1 mL of IP contrast agent (20 mg iodine/mL) administered 10 min before PET/CT acquisition. Phantom studies showed that the use of a 20-mg iodine/mL concentration of Omnipaque® led to a 4.8% overestimation of radioactivity concentration, as compared to saline. This was confirmed by animal studies that demonstrated a 4.3% overestimation. Tumor detection was excellent and correlation between PET/CT quantitative data and ex vivo counting was good (r (2) = 0.91, slope = 0.7). CONCLUSIONS: A dual radiologic contrast protocol is useful in PET/CT scanning of mice bearing abdominal tumors. Contrast agents used in this manner lead to a small but acceptable overestimation of quantitative PET data. |
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Authors:
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Nicolas Aide; Kathryn Kinross; Jean-Mathieu Beauregard; Oliver Neels; Titaina Potdevin; Peter Roselt; Donna Dorow; Carleen Cullinane; Rodney J Hicks |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Molecular imaging and biology : MIB : the official publication of the Academy of Molecular Imaging Volume: 13 ISSN: 1860-2002 ISO Abbreviation: Mol Imaging Biol Publication Date: 2011 Jun |
Date Detail:
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Created Date: 2011-05-05 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101125610 Medline TA: Mol Imaging Biol Country: United States |
Other Details:
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Languages: eng Pagination: 518-25 Citation Subset: IM |
Affiliation:
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Bioticla Team, EA 1772, IFR 146 ICORE, GRECAN, François Baclesse Cancer Centre and Caen University, Caen, France, n.aide@baclesse.fr. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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