| Dual Properties of Anticancer Agents: An Exploratory Study on the in vitro Anti-Candida Properties of Thirty Drugs. | |
| | |
MedLine Citation:
|
PMID: 21997126 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
Background: Anticancer/antineoplastic agents could be a good resource for the discovery of novel antifungal agents and targets since human beings share a common eukaryotic heritage with fungi. Methods: Thirty commonly prescribed anticancer drugs belonging to 12 different classes were analyzed for their effects on the growth of Candida albicans. Minimum inhibitory concentrations (MICs) were obtained using standard CLSI-M27 A2 methodology, and minimal fungicidal concentrations (MFCs) were determined via the agar plate method. Results: Anticancer agents inhibited the growth of C. albicans in a concentration-dependent manner. Nine drugs from different classes were effective at low concentrations (≤50 μg·ml(-1)), while 15 anticancer drugs exhibited MICs of 100 μg·ml(-1). Sixteen out of 30 drugs exerted fungicidal activity in the range of 400-800 μg·ml(-1). Conclusions: MICs and MFCs for 30 anticancer drugs were established against C. albicans. Our study highlighted the anti-Candida potential of these drugs, which may give insights to unexplored targets for antifungal chemotherapy. |
| | |
Authors:
|
Madhushree M Routh; Jayant S Raut; S Mohan Karuppayil |
Related Documents
:
|
22209456 - Dithiocarbamates are strong inhibitors of the beta-class fungal carbonic anhydrases fro... 14732886 - Guidelines for the treatment of primary central nervous system lymphomas in immunocompe... 11824426 - Venlafaxine and generalised anxiety disorder: new preparation. minimise recourse to drugs. 22212016 - Ctbt (7-chlorotetrazolo[5,1-c]benzo[1,2,4]triazine) producing ros affects growth and vi... 16525816 - Investigation of sarizotan's impact on the pharmacokinetics of probe drugs for major cy... 20132126 - Drug interactions between antiretroviral medications and medications used in the treatm... |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2011-10-11 |
Journal Detail:
|
Title: Chemotherapy Volume: 57 ISSN: 1421-9794 ISO Abbreviation: - Publication Date: 2011 Oct |
Date Detail:
|
Created Date: 2011-10-14 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0144731 Medline TA: Chemotherapy Country: - |
Other Details:
|
Languages: ENG Pagination: 372-380 Citation Subset: - |
Copyright Information:
|
Copyright © 2011 S. Karger AG, Basel. |
Affiliation:
|
DST-FIST Sponsored School of Life Sciences, SRTM University, Nanded, India. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Disseminated Nocardia farcinica infection in a patient with myasthenia gravis successfully treated b...
Next Document: Influence of body position, PEEP and intra-abdominal pressure on the catheter positioning for neural...