Document Detail


Dual Properties of Anticancer Agents: An Exploratory Study on the in vitro Anti-Candida Properties of Thirty Drugs.
MedLine Citation:
PMID:  21997126     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Background: Anticancer/antineoplastic agents could be a good resource for the discovery of novel antifungal agents and targets since human beings share a common eukaryotic heritage with fungi. Methods: Thirty commonly prescribed anticancer drugs belonging to 12 different classes were analyzed for their effects on the growth of Candida albicans. Minimum inhibitory concentrations (MICs) were obtained using standard CLSI-M27 A2 methodology, and minimal fungicidal concentrations (MFCs) were determined via the agar plate method. Results: Anticancer agents inhibited the growth of C. albicans in a concentration-dependent manner. Nine drugs from different classes were effective at low concentrations (≤50 μg·ml(-1)), while 15 anticancer drugs exhibited MICs of 100 μg·ml(-1). Sixteen out of 30 drugs exerted fungicidal activity in the range of 400-800 μg·ml(-1). Conclusions: MICs and MFCs for 30 anticancer drugs were established against C. albicans. Our study highlighted the anti-Candida potential of these drugs, which may give insights to unexplored targets for antifungal chemotherapy.
Authors:
Madhushree M Routh; Jayant S Raut; S Mohan Karuppayil
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-10-11
Journal Detail:
Title:  Chemotherapy     Volume:  57     ISSN:  1421-9794     ISO Abbreviation:  -     Publication Date:  2011 Oct 
Date Detail:
Created Date:  2011-10-14     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0144731     Medline TA:  Chemotherapy     Country:  -    
Other Details:
Languages:  ENG     Pagination:  372-380     Citation Subset:  -    
Copyright Information:
Copyright © 2011 S. Karger AG, Basel.
Affiliation:
DST-FIST Sponsored School of Life Sciences, SRTM University, Nanded, India.
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