Document Detail

A dual mode pulsed electro-magnetic cell stimulator produces acceleration of myogenic differentiation.
MedLine Citation:
PMID:  23445453     Owner:  NLM     Status:  MEDLINE    
This paper presents the design and test of a dual-mode electric and magnetic biological stimulator (EM-Stim). The stimulator generates pulsing electric and magnetic fields at programmable rates and intensities. While electric and magnetic stimulators have been reported before, this is the first device that combines both modalities. The ability of the dual stimulation to target bone and muscle tissue simultaneously has the potential to improve the therapeutic treatment of osteoporosis and sarcopenia. The device is fully programmable, portable and easy to use, and can run from a battery or a power supply. The device can generate magnetic fields of up to 1.6 mT and output voltages of +/- 40 V. The EM-Stim accelerated myogenic differentiation of myoblasts into myotubes as evidenced by morphometric, gene expression, and protein content analyses. Currently, there are many patents concerned with the application of single electrical or magnetic stimulation, but none that combine both simultaneously. However, we applied for and obtained a provisional patent for new device to fully explore its therapeutic potential in pre-clinical models.
Walter D Leon-Salas; Hatem Rizk; Chenglin Mo; Noah Weisleder; Leticia Brotto; Eduardo Abreu; Marco Brotto
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Recent patents on biotechnology     Volume:  7     ISSN:  2212-4012     ISO Abbreviation:  Recent Pat Biotechnol     Publication Date:  2013 Apr 
Date Detail:
Created Date:  2013-10-31     Completed Date:  2014-05-08     Revised Date:  2014-05-30    
Medline Journal Info:
Nlm Unique ID:  101309942     Medline TA:  Recent Pat Biotechnol     Country:  United Arab Emirates    
Other Details:
Languages:  eng     Pagination:  71-81     Citation Subset:  IM    
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MeSH Terms
Cell Differentiation / physiology
Cell Growth Processes / physiology
Cell Line
Cytological Techniques / instrumentation*,  methods*
Electric Stimulation / instrumentation*
Electromagnetic Fields
Muscle Development / physiology*
Myoblasts / cytology*
Patents as Topic
Grant Support
1RC2AR058962-01/AR/NIAMS NIH HHS; AG039355-01A1/AG/NIA NIH HHS; P01 AG039355/AG/NIA NIH HHS; R01 AR063084/AR/NIAMS NIH HHS

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