| Dual functional polyelectrolyte multilayer coatings for implants: permanent microbicidal base with controlled release of therapeutic agents. | |
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MedLine Citation:
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PMID: 21105659 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Here we present a new bifunctional layer-by-layer (LbL) construct made by combining a permanent microbicidal polyelectrolyte multilayered (PEM) base film with a hydrolytically degradable PEM top film that offers controlled and localized delivery of therapeutics. Two degradable film architectures are presented: (1) bolus release of an antibiotic (gentamicin) to eradicate initial infection at the implant site, or (2) sustained delivery of an anti-inflammatory drug (diclofenac) to cope with inflammation at the site of implantation due to tissue injury. Each degradable film was built on top of a permanent base film that imparts the implantable device surface with microbicidal functionality that prevents the formation of biofilms. Controlled-delivery of gentamicin was demonstrated over hours and that of diclofenac over days. Both drugs retained their efficacy upon release. The permanent microbicidal base film was biocompatible with A549 epithelial cancer cells and MC3T3-E1 osteoprogenitor cells, while also preventing bacteria attachment from turbid media for the entire duration of the two weeks studied. The microbicidal base film retains its functionality after the biodegradable films have completely degraded. The versatility of these PEM films and their ability to prevent biofilm formation make them attractive as coatings for implantable devices. |
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Authors:
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Sze Yinn Wong; Joshua S Moskowitz; Jovana Veselinovic; Ryan A Rosario; Ksenia Timachova; Michael R Blaisse; Renée C Fuller; Alexander M Klibanov; Paula T Hammond |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S. Date: 2010-11-24 |
Journal Detail:
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Title: Journal of the American Chemical Society Volume: 132 ISSN: 1520-5126 ISO Abbreviation: J. Am. Chem. Soc. Publication Date: 2010 Dec |
Date Detail:
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Created Date: 2010-12-15 Completed Date: 2011-03-29 Revised Date: 2012-10-09 |
Medline Journal Info:
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Nlm Unique ID: 7503056 Medline TA: J Am Chem Soc Country: United States |
Other Details:
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Languages: eng Pagination: 17840-8 Citation Subset: IM |
Affiliation:
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Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, United States. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Anti-Infective Agents
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pharmacology Cell Line, Tumor Coated Materials, Biocompatible / chemistry* Delayed-Action Preparations Diclofenac / pharmacology* Drug Implants Gentamicins / pharmacology* Humans Models, Biological Molecular Structure Polymers / chemistry* Surface Properties |
| Grant Support | |
ID/Acronym/Agency:
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5R01AG029601-03/AG/NIA NIH HHS; R01 AG029601-01/AG/NIA NIH HHS; R01 AG029601-05/AG/NIA NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Anti-Infective Agents; 0/Coated Materials, Biocompatible; 0/Delayed-Action Preparations; 0/Drug Implants; 0/Gentamicins; 0/Polymers; 0/poly(beta-amino ester); 15307-86-5/Diclofenac |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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