| Dscam and neuronal uniqueness. | |
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MedLine Citation:
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PMID: 17482538 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In the fruit fly Drosophila the gene encoding the cell adhesion molecule Dscam generates alternatively spliced mRNAs that can be translated into thousands of different protein isoforms. Three recent papers show that isoform-specific homophilic Dscam interactions cause dendritic branches of the same neuron to avoid each other (Hughes et al., 2007; Soba et al., 2007; Matthews et al., 2007). This process ensures the correct patterning of dendrites in the peripheral nervous system. |
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Authors:
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Kai Zinn |
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Publication Detail:
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Type: Comment; Journal Article |
Journal Detail:
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Title: Cell Volume: 129 ISSN: 0092-8674 ISO Abbreviation: Cell Publication Date: 2007 May |
Date Detail:
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Created Date: 2007-05-07 Completed Date: 2007-06-20 Revised Date: 2009-11-19 |
Medline Journal Info:
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Nlm Unique ID: 0413066 Medline TA: Cell Country: United States |
Other Details:
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Languages: eng Pagination: 455-6 Citation Subset: IM |
Affiliation:
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Division of Biology, California Institute of Technology, Pasadena, CA 91125, USA. zinnk@caltech.edu <zinnk@caltech.edu> |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Alternative Splicing Animals Cell Adhesion Molecules Dendrites / metabolism* Drosophila / embryology* Drosophila Proteins / genetics*, metabolism Gene Expression Regulation, Developmental Neurons / cytology*, metabolism Peripheral Nervous System / cytology, embryology Protein Isoforms |
| Chemical | |
Reg. No./Substance:
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0/Cell Adhesion Molecules; 0/Drosophila Proteins; 0/Dscam protein, Drosophila; 0/Protein Isoforms |
| Comments/Corrections | |
Comment On:
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Cell. 2007 May 4;129(3):593-604
[PMID:
17482551
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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