Document Detail


Dry skin, barrier function, and irritant contact dermatitis in the elderly.
MedLine Citation:
PMID:  21146729     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Dry skin is characterized by a decreased lipid content and a delayed reconstitution of the epidermal barrier after skin irritation. These are problems of high relevance in the aged population, especially in the development of irritant contact dermatitis. Asteatotic and perineal irritant dermatitis are the most important subtypes of irritant contact dermatitis in the elderly. This contribution presents a compressed survey on these subtypes and elucidates their relation to an impaired barrier function. Typical irritants affecting aged individuals are explained and compared with irritants that seem to be more significant in younger people. Results of biophysical investigations, such as measurement of transepidermal water loss, are discussed regarding their age-dependence. Transepidermal water loss decreases with age, which was formerly interpreted as an indication of a decreased sensitivity. Today, we know that reconstitution of the epidermal barrier after irritation is delayed once it has been impaired. Reasons are decreased activities of enzymes involved in lipid synthesis and processing, a changed cytokine profile, a reduced acidification of aged skin, and alterations in the function of epidermal stem cells. Owing to these new insights, a reevaluation of the sensitivity of aged skin has to be initiated, especially with regard to occupational dermatology.
Authors:
Florian Seyfarth; Sibylle Schliemann; Dimitar Antonov; Peter Elsner
Related Documents :
17684529 - Endocrine regulation of ageing.
21426259 - Regulatory t-cell adoptive immunotherapy: potential for treatment of autoimmunity.
25137369 - Accelerometer adherence and performance in a cohort study of us hispanic adults.
24153069 - Measurement of subfoveal choroidal thickness using spectral domain optical coherence to...
21489069 - Understanding young and older male drivers' willingness to drive while intoxicated: the...
23940909 - Prevalence of cholelithiasis in buenos aires, argentina.
9203869 - Age-related changes in human anterior cruciate ligament (acl) collagen fibrils.
9811369 - Relationship between plasma testosterone and urinary felinine in the growing kitten.
1496949 - Growth hormone therapy in turner's syndrome. impact of injection frequency and initial ...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Clinics in dermatology     Volume:  29     ISSN:  1879-1131     ISO Abbreviation:  Clin. Dermatol.     Publication Date:    2011 Jan-Feb
Date Detail:
Created Date:  2010-12-14     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8406412     Medline TA:  Clin Dermatol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  31-6     Citation Subset:  IM    
Copyright Information:
Copyright © 2011 Elsevier Inc. All rights reserved.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Contact sensitization in the elderly.
Next Document:  Dry skin in the elderly: Complexities of a common problem.