Document Detail

Drugs that interact with cardiac electro-mechanics: old and new targets for treatment.
MedLine Citation:
PMID:  18406454     Owner:  NLM     Status:  MEDLINE    
The concept of mechano-electrical feedback was derived from the observation that a short stretch applied to the beating heart can invoke an electrical response in the form of an afterdepolarization or a premature ventricular beat. More recent work has identified stretch-activated channels whose specific inhibition might help to treat atrial fibrillation in the near future. But the interaction between electrical and mechanical function of the heart is a continuum from short-term (within milliseconds) to long-term (within weeks or months) effects. The long-term effects of pressure overload have been well-described on the molecular and cellular level, and substances that interact with these processes are used in clinical routine in the care of patients with cardiac hypertrophy and heart failure. These treatments help to prevent lethal arrhythmias (sudden death) and potentially atrial fibrillation. The intermediate interaction between mechanical and electrical function of the heart is less well-understood. Several recently identified regulatory mechanisms may provide novel antiarrhythmic targets associated with the "intermediate" response of the myocardium to stretch.
Paulus Kirchhof; Lisa Fortmüller; Christoph Waldeyer; Günter Breithardt; Larissa Fabritz
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review     Date:  2008-02-12
Journal Detail:
Title:  Progress in biophysics and molecular biology     Volume:  97     ISSN:  0079-6107     ISO Abbreviation:  Prog. Biophys. Mol. Biol.     Publication Date:    2008 Jun-Jul
Date Detail:
Created Date:  2008-06-20     Completed Date:  2008-09-12     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0401233     Medline TA:  Prog Biophys Mol Biol     Country:  England    
Other Details:
Languages:  eng     Pagination:  497-512     Citation Subset:  IM    
Department of Cardiology and Angiology, Hospital of the University of Münster, Münster, Germany.
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MeSH Terms
Anti-Arrhythmia Agents / pharmacology*,  therapeutic use
Aortic Valve Stenosis / drug therapy,  physiopathology
Atrial Fibrillation / drug therapy,  metabolism,  physiopathology
Calcium / physiology
Cardiomegaly / drug therapy,  physiopathology
Heart Conduction System / drug effects
Mechanotransduction, Cellular
Mitral Valve Stenosis / drug therapy,  physiopathology
Myocardial Contraction / drug effects,  physiology*
Sodium / metabolism*
Ventricular Fibrillation / drug therapy,  physiopathology
Reg. No./Substance:
0/Anti-Arrhythmia Agents; 7440-23-5/Sodium; 7440-70-2/Calcium

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