Document Detail

Drugs in pregnancy. Anticoagulants.
MedLine Citation:
PMID:  11800528     Owner:  NLM     Status:  MEDLINE    
Pregnancy is a period of heightened coagulability and enhanced risk for thrombotic complications. Thromboembolism is the leading cause of maternal mortality. Anticoagulants are very useful during pregnancy for the acute treatment of venous thromboembolism and for the prevention of recurrent venous thromboembolism. They may also be beneficial in patients with thrombophilias, particularly among women who have experienced adverse pregnancy outcomes such as recurrent pregnancy loss. Anticoagulation is essential but problematic in the management of pregnant women with mechanical heart valve prostheses. When utilizing these medications among pregnant women the potential benefits must be balanced against the possibility of maternal haemorrhagic complications, adverse effects on the pregnancy or toxic effects on the fetus. This chapter summarizes current knowledge about the anticoagulant agents, their potential toxicities and their therapeutic role in pregnant women with various indications for anticoagulant therapy.
P S Gibson; K Rosene-Montella
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Best practice & research. Clinical obstetrics & gynaecology     Volume:  15     ISSN:  1521-6934     ISO Abbreviation:  Best Pract Res Clin Obstet Gynaecol     Publication Date:  2001 Dec 
Date Detail:
Created Date:  2002-01-21     Completed Date:  2002-01-31     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  101121582     Medline TA:  Best Pract Res Clin Obstet Gynaecol     Country:  England    
Other Details:
Languages:  eng     Pagination:  847-61     Citation Subset:  IM    
Copyright Information:
Copyright 2001 Harcourt Publishers Ltd.
Division of Obstetric and Consultative Medicine, Department of Medicine, Women and Infants' Hospital of Rhode Island and Brown University School of Medicine, Providence 02095, USA.
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MeSH Terms
Abortion, Habitual / prevention & control
Anticoagulants / therapeutic use*
Heart Valve Prosthesis / adverse effects
Pregnancy Complications, Hematologic / prevention & control*
Thromboembolism / prevention & control*
Thrombophilia / drug therapy
Venous Thrombosis / prevention & control*
Reg. No./Substance:

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