Document Detail

Drugs for cough and cold symptoms in hypertensive patients.
MedLine Citation:
PMID:  3976459     Owner:  NLM     Status:  MEDLINE    
Most cold preparations contain sympathomimetic decongestants in combination with antihistamines, anticholinergics or expectorants. All of the sympathomimetic decongestants have the potential to elevate blood pressure, yet little information has been reported on their use in patients with hypertension. Phenylephrine and phenylpropanolamine stimulate alpha-adrenergic receptors, causing elevation of blood pressure and a reflex decrease in heart rate. Ephedrine and pseudoephedrine stimulate both alpha and beta receptors, elevating blood pressure with an increase or no change in heart rate. Because little is clinically known, these agents should probably be avoided in hypertensives.
W B White; K Riotte
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  American family physician     Volume:  31     ISSN:  0002-838X     ISO Abbreviation:  Am Fam Physician     Publication Date:  1985 Mar 
Date Detail:
Created Date:  1985-04-24     Completed Date:  1985-04-24     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  1272646     Medline TA:  Am Fam Physician     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  183-7     Citation Subset:  AIM; IM    
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MeSH Terms
Antitussive Agents / pharmacology*
Blood Pressure / drug effects
Cardiovascular Diseases / chemically induced
Common Cold / complications,  drug therapy*
Cough / complications,  drug therapy*
Ephedrine / pharmacology
Hypertension / complications*
Phenylephrine / pharmacology
Phenylpropanolamine / pharmacology
Vasoconstrictor Agents / pharmacology*,  poisoning
Reg. No./Substance:
0/Antitussive Agents; 0/Vasoconstrictor Agents; 14838-15-4/Phenylpropanolamine; 299-42-3/Ephedrine; 59-42-7/Phenylephrine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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