Document Detail

Drug utilisation in very preterm infants: any changes during the past decade?
MedLine Citation:
PMID:  18401813     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Improved standards of perinatal care for preterm infants led to decreased hospital mortality rates during the past decade. However, studies investigating changes in drug utilisation in neonatal intensive care units (NICU) during this period are missing. OBJECTIVE: The aim of the present study therefore was to evaluate the most frequently used groups of drugs in preterm infants treated in NICUs and to analyse potential changes in drug utilisation over a period of ten years. METHODS: Drug utilisation patterns in 164 preterm infants born between 1989 and 1990 (group I; gestational age 27.2+/-1.2 weeks, birth weight 970+/-145 g) were compared to those in 113 preterm infants born between 2001 and 2004 (group II; gestational age 26.9+/-1.65 weeks, birth weight 930+/-253 g, mean and standard deviation each) with need for postnatal mechanical ventilation. RESULTS: Significant changes in drug utilisation patterns were observed for complete courses of antenatal corticosteroids (40 vs. 51.5%), diuretics (78 vs. 36.6%), surfactant (63.3 vs. 75%), methylxanthines (89.9 vs. 56.7%), sedatives/analgesics (82.4 vs. 91.5%) and catecholamines (38.3 vs. 52.4%) (group II vs. group I each). Postnatal corticosteroids were applied more often in group II (17.4 vs. 13.4%). However, duration of postnatal corticosteroid treatment has decreased (6 d vs. 13 d). The use of antibiotics remained unchanged (100 vs. 98.9%). Comparison of clinical outcome variables showed a decreased duration of mechanical ventilation and a significantly increased survival rate. CONCLUSION: Drug utilisation patterns in preterms have changed considerably during the past decade. Improved standards of care and shorter duration of mechanical ventilation may be operative.
U Lindner; A Hilgendorff; G Frey; L Gortner
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't     Date:  2008-04-09
Journal Detail:
Title:  Klinische Pädiatrie     Volume:  220     ISSN:  0300-8630     ISO Abbreviation:  Klin Padiatr     Publication Date:    2008 Jul-Aug
Date Detail:
Created Date:  2008-07-25     Completed Date:  2008-10-01     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0326144     Medline TA:  Klin Padiatr     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  238-42     Citation Subset:  IM    
Klinik für Allgemeine Pädiatrie und Neonatologie, Universitätskliniken des Saarlandes, Homburg/Saar.
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MeSH Terms
Adrenal Cortex Hormones / therapeutic use
Analgesics / therapeutic use
Anti-Bacterial Agents / therapeutic use
Catecholamines / therapeutic use
Cohort Studies
Diuretics / therapeutic use
Drug Utilization Review / trends*
Gestational Age
Hypnotics and Sedatives / therapeutic use
Infant, Extremely Low Birth Weight
Infant, Newborn
Infant, Premature, Diseases / drug therapy*
Infant, Very Low Birth Weight
Multicenter Studies as Topic
Pulmonary Surfactants / therapeutic use
Randomized Controlled Trials as Topic
Respiration, Artificial*
Respiratory Distress Syndrome, Newborn / drug therapy*
Xanthines / therapeutic use
Reg. No./Substance:
0/Adrenal Cortex Hormones; 0/Analgesics; 0/Anti-Bacterial Agents; 0/Catecholamines; 0/Diuretics; 0/Hypnotics and Sedatives; 0/Pulmonary Surfactants; 0/Xanthines; 28109-92-4/methylxanthine

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