| Drug use and toxicity in psoriatic disease: focus on methotrexate. | |
| | |
MedLine Citation:
|
PMID: 18609744 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Methotrexate (MTX) toxicity in psoriatic disease was the focus of discussion at the 2007 Annual Meeting of the Group for Research and Assessment of Psoriasis and Psoriatic Arthritis (GRAPPA). Plenary presentations and results of a Web-based opinion survey of rheumatologists and dermatologists from GRAPPA, and others from New Zealand, Australia, and Canada, provided topics of discussion for small-group breakout sessions, including hepatotoxicity, alcohol use, fertility and pregnancy, and combination therapy. As a framework, topics were considered under headings: importance, knowledge deficit, sufficient data for a recommendation, and research agenda. Breakout session conclusions/consensus were as follows: (1) Data are insufficient to recommend routine serial liver biopsy to prevent MTX-induced liver fibrosis; further research is needed to establish whether serial liver chemistry tests or propeptide of type III collagen can detect hepatotoxicity without the need for liver biopsy. (2) Insufficient data are available to establish a dose-response relationship between alcohol use and MTX hepatotoxicity, so no safe limit of alcohol intake can be recommended. (3) Although cessation of MTX 3 months prior to conception is reasonable, inadequate data are available to specify duration or to quantify the risk of adverse fetal outcome; registries to track pregnancy outcome are potentially useful. (4) Combination therapy with anti-TNF agents or sulfasalazine is safe, but insufficient data are available for combinations with leflunomide or cyclosporine. |
| | |
Authors:
|
William J Taylor; Eleanor Korendowych; Peter Nash; Philip S Helliwell; Ernest Choy; Gerald G Krueger; Enrique R Soriano; Neil J McHugh; Cheryl F Rosen |
Related Documents
:
|
19646734 - Maternal exposure to floricultural work during pregnancy, pon1 q192r polymorphisms and ... 18640664 - Effects of binge alcohol exposure in the second trimester on intracerebral arteriolar f... 20451334 - A prospective study on intrauterine cannabis exposure and fetal blood flow. 277064 - Dietary cravings and aversions during pregnancy. 8365534 - Lack of associations between fetal and maternal serum-erythropoietin at birth. 14747194 - Influences of maternal weight on the secondary sex ratio of human offspring. |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: The Journal of rheumatology Volume: 35 ISSN: 0315-162X ISO Abbreviation: J. Rheumatol. Publication Date: 2008 Jul |
Date Detail:
|
Created Date: 2008-07-08 Completed Date: 2008-12-02 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 7501984 Medline TA: J Rheumatol Country: Canada |
Other Details:
|
Languages: eng Pagination: 1454-7 Citation Subset: IM |
Affiliation:
|
Department of Medicine, University of Otago/Wellington, New Zealand. will.taylor@otago.ac.nz |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Alcoholic Beverages
/
adverse effects Antirheumatic Agents / adverse effects* Female Humans Liver Cirrhosis / chemically induced Methotrexate / adverse effects* Pregnancy Psoriasis / drug therapy* |
| Chemical | |
Reg. No./Substance:
|
0/Antirheumatic Agents; 59-05-2/Methotrexate |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Genetics of psoriasis and psoriatic arthritis: update and future direction.
Next Document: Clinical and genetic registries in psoriatic disease.