| Drug treatment of multidrug-resistant osteoarticular tuberculosis: a systematic literature review. | |
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MedLine Citation:
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PMID: 22940279 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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OBJECTIVE: To review the literature in order to determine the best treatment options for multidrug-resistant tuberculosis (MDR-TB) of the skeletal system. METHODS: We searched the PubMed database for all case reports of osteoarticular MDR-TB that provided information on drug treatment and clinical outcome. RESULTS: We identified six cases with spinal MDR-TB and seven with extraspinal MDR-TB and reviewed their susceptibility tests, treatments administered, surgical treatments, and clinical outcomes. All patients had a successful clinical outcome (either cured or improved) except one who died due to septicemia. One patient with spinal MDR-TB and four patients with extraspinal MDR-TB had a successful outcome with medical treatment alone. Two patients who received treatment for a shorter time or with fewer drugs than recommended were cured with the addition of surgery. CONCLUSIONS: Osteoarticular MDR-TB is very infrequently reported in the literature. The few cases reviewed suggest that it is possible to achieve a good outcome with second-line anti-tuberculous drugs, and that surgery might be useful for cases in which an optimized medical treatment is not possible. |
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Authors:
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Inés Suárez-García; Arturo Noguerado |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-8-30 |
Journal Detail:
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Title: International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases Volume: - ISSN: 1878-3511 ISO Abbreviation: Int. J. Infect. Dis. Publication Date: 2012 Aug |
Date Detail:
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Created Date: 2012-9-3 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9610933 Medline TA: Int J Infect Dis Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2012 International Society for Infectious Diseases. Published by Elsevier Ltd. All rights reserved. |
Affiliation:
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Infectious Diseases Unit, Department of Internal Medicine, Hospital Infanta Sofía, Paseo de Europa, 34, 28702 San Sebastián de los Reyes, Madrid, Spain. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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