Document Detail

Drug treatment of hypertriglyceridaemia in chronic uraemic patients: preliminary report on D,L-carnitine and thiadenol.
MedLine Citation:
PMID:  7243794     Owner:  NLM     Status:  MEDLINE    
Clofibrate (a very effective lipid-lowering drug) may cause serious muscular damage in uraemic patients, even if used at appropriately low dose. Some authors have reported that D,L-Carnitine and Thiadenol can reduce lipid levels in non uraemic subjects, without adverse effects. In our study D,L-Carnitine and Thiadenol were administered for 3 months to respectively 21 and 15 patients on chronic haemodialysis with hypertriglyceridaemia. With D,L-Carnitine 52% of patients showed lower plasma triglycerides (TG) (-40.6%, p less than 0.002); after Thiadenol 66.6% of patients showed reduced plasma TG concentration (-42.9%, p less than 0.001). No dietary changes were recorded during the study. No major side effects nor biochemical changes were observed. D,L-Carnitine and Thiadenol appear to be less effective, but also less dangerous than Clofibrate in chronic uraemic patients.
G Giorcelli; G Vacha; G P Icardi
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Proceedings of the European Dialysis and Transplant Association. European Dialysis and Transplant Association     Volume:  17     ISSN:  0071-2736     ISO Abbreviation:  Proc Eur Dial Transplant Assoc     Publication Date:  1980  
Date Detail:
Created Date:  1981-08-10     Completed Date:  1981-08-10     Revised Date:  2008-02-21    
Medline Journal Info:
Nlm Unique ID:  0355210     Medline TA:  Proc Eur Dial Transplant Assoc     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  367-71     Citation Subset:  IM    
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MeSH Terms
Carnitine / therapeutic use*
Chronic Disease
Clofibrate / therapeutic use
Fatty Alcohols / therapeutic use*
Hyperlipoproteinemias / complications,  drug therapy*
Lipid Metabolism
Renal Dialysis
Uremia / complications*
Reg. No./Substance:
0/Fatty Alcohols; 541-15-1/Carnitine; 637-07-0/Clofibrate; 6964-20-1/tiadenol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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