| Drug treatment of hypertriglyceridaemia in chronic uraemic patients: preliminary report on D,L-carnitine and thiadenol. | |
MedLine Citation:
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PMID: 7243794 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Clofibrate (a very effective lipid-lowering drug) may cause serious muscular damage in uraemic patients, even if used at appropriately low dose. Some authors have reported that D,L-Carnitine and Thiadenol can reduce lipid levels in non uraemic subjects, without adverse effects. In our study D,L-Carnitine and Thiadenol were administered for 3 months to respectively 21 and 15 patients on chronic haemodialysis with hypertriglyceridaemia. With D,L-Carnitine 52% of patients showed lower plasma triglycerides (TG) (-40.6%, p less than 0.002); after Thiadenol 66.6% of patients showed reduced plasma TG concentration (-42.9%, p less than 0.001). No dietary changes were recorded during the study. No major side effects nor biochemical changes were observed. D,L-Carnitine and Thiadenol appear to be less effective, but also less dangerous than Clofibrate in chronic uraemic patients. |
Authors:
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G Giorcelli; G Vacha; G P Icardi |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: Proceedings of the European Dialysis and Transplant Association. European Dialysis and Transplant Association Volume: 17 ISSN: 0071-2736 ISO Abbreviation: Proc Eur Dial Transplant Assoc Publication Date: 1980 |
Date Detail:
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Created Date: 1981-08-10 Completed Date: 1981-08-10 Revised Date: 2008-02-21 |
Medline Journal Info:
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Nlm Unique ID: 0355210 Medline TA: Proc Eur Dial Transplant Assoc Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 367-71 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Carnitine
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therapeutic use* Chronic Disease Clofibrate / therapeutic use Fatty Alcohols / therapeutic use* Humans Hyperlipoproteinemias / complications, drug therapy* Lipid Metabolism Renal Dialysis Uremia / complications* |
| Chemical | |
Reg. No./Substance:
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0/Fatty Alcohols; 541-15-1/Carnitine; 637-07-0/Clofibrate; 6964-20-1/tiadenol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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