Document Detail


Drug treatment of breathlessness: contrasting effects of diazepam and promethazine in pink puffers.
MedLine Citation:
PMID:  6788319     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Fifteen out of 18 "pink and puffing" patients completed a double-blind, placebo-controlled cross-over trial of diazepam and promethazine for breathlessness and reduced exercise tolerance. Dosages were 25 mg and 125 mg daily, respectively, and each course lasted two weeks. Patients with psychiatric or other major medical histories were excluded. Of the three patients who did not complete the trial, one died during an exacerbation of breathlessness while taking diazepam, one was withdrawn because of mild hypercapnia while taking placebo, and one suffered intolerable drowsiness while taking diazepam. Of the remaining 15 patients, six needed a reduction in dosage because of drowsiness: one of these was taking promethazine and five diazepam. Diazepam had no effect on breathlessness and noticeably reduced exercise tolerance. Promethazine reduced breathlessness and improved exercise tolerance without altering lung function. From these results diazepam is contraindicated for breathlessness and reduced exercise tolerance in fixed airways obstruction, but promethazine may be beneficial.
Authors:
A A Woodcock; E R Gross; D M Geddes
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  British medical journal (Clinical research ed.)     Volume:  283     ISSN:  0267-0623     ISO Abbreviation:  Br Med J (Clin Res Ed)     Publication Date:  1981 Aug 
Date Detail:
Created Date:  1981-09-22     Completed Date:  1981-09-22     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  8302911     Medline TA:  Br Med J (Clin Res Ed)     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  343-6     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Clinical Trials as Topic
Diazepam / adverse effects,  therapeutic use*
Double-Blind Method
Female
Humans
Lung Diseases, Obstructive / drug therapy
Male
Middle Aged
Physical Exertion
Promethazine / adverse effects,  therapeutic use*
Respiratory Function Tests
Respiratory Insufficiency / drug therapy*
Chemical
Reg. No./Substance:
439-14-5/Diazepam; 60-87-7/Promethazine
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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