| Drug therapy of inflammatory bowel disease. | |
| | |
MedLine Citation:
|
PMID: 15010706 Owner: NLM Status: PubMed-not-MEDLINE |
Abstract/OtherAbstract:
|
The drugs that are effective in inflammatory bowel disease (IBD) act by inhibiting the chronic unregulated intestinal inflammation in these patients. The mainstays of the drug therapy of IBD are a variety of formulations of 5-aminosalicylic acid (5-ASA), the conventional and newer low bioavailability glucocorticoids, the nitroimidazole antibiotic metronidazole, and certain immunomodulating agents. Increased understanding of the mechanisms of inflammation in IBD has permitted the development of effective designer drugs. These agents are products of the biotechnology industry and include antibodies to tumor necrosis factor (TNF)-alpha, antisense oligonucleotides and recombinant human interleukin (IL)-10. In addition, a number of other agents such as nicotine and n-3 fatty acids are useful in certain patients. This review first focuses on the pharmacology and mechanism of action of these drugs in IBD, followed by an approach to the treatment of patients with ulcerative colitis (UC) and Crohns disease (CD). The recommendations consider type and activity of IBD and are based largely on data from controlled trials and systematic reviews in the IBD literature. |
| | |
Authors:
|
L J Egan; W J Sandborn |
Related Documents
:
|
11508686 - Protective effect of amtolmetin guacyl versus placebo diclofenac and misoprostol in hea... 98666 - Observations on acute gastric dilatation in nonhuman primates. 22536546 - Advances in corticosteroid therapy for ocular inflammation: loteprednol etabonate. 7863246 - Drug interactions of h2-receptor antagonists. 18065216 - Transdermal delivery of penetrants with differing lipophilicities using o-acylmenthol d... 21671356 - One step forward: the use of transgenic zebrafish tumor model in drug screens. |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Drugs of today (Barcelona, Spain : 1998) Volume: 34 ISSN: 1699-3993 ISO Abbreviation: Drugs Today Publication Date: 1998 May |
Date Detail:
|
Created Date: 2004-03-10 Completed Date: 2004-03-23 Revised Date: 2006-10-26 |
Medline Journal Info:
|
Nlm Unique ID: 101160518 Medline TA: Drugs Today (Barc) Country: Spain |
Other Details:
|
Languages: eng Pagination: 431-46 Citation Subset: - |
Affiliation:
|
Inflammatory Bowel Disease Clinic, Division of Gastroenterology and Hepatology, Mayo Clinic and Foundation, Rochester, Minnesota 55905, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Central neurological paraneoplastic syndromes. Part 1. Clinical features, pathophysiology and immuno...
Next Document: Dry eye syndrome.