| Drug therapy or coronary angioplasty for the treatment of coronary artery disease: new insights. | |
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MedLine Citation:
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PMID: 11174355 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: In the last decade percutaneous transluminal coronary angioplasty has become a very popular strategy for the treatment of coronary artery disease, although its efficacy in reducing ischemic events and the subsequent need for revascularization has yet to be proved. METHODS: We reviewed the latest trials that compared percutaneous transluminal coronary angioplasty and medical therapy. RESULTS: We discuss the potentially favorable effect of lipid-lowering therapy on coronary atherosclerosis and cardiac events and comment on the results of the recent Atorvastatin Versus Revascularization Treatments (AVERT) study that compared lipid-lowering treatment and percutaneous transluminal coronary angioplasty in patients with stable coronary artery disease. CONCLUSIONS: Medical treatment aimed at reversing plaque growth and promoting plaque stabilization should probably be considered as the initial therapeutic option. Statin class drugs, together with aggressive management of known risk factors, show promise as the first step after appropriate early diagnosis. Revascularization procedures should subsequently be considered for all patients who do not respond to medical treatment or in whom the disease shows clear signs of progression. |
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Authors:
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G Amoroso; A J Van Boven; H J Crijns |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: American heart journal Volume: 141 ISSN: 0002-8703 ISO Abbreviation: Am. Heart J. Publication Date: 2001 Feb |
Date Detail:
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Created Date: 2001-02-22 Completed Date: 2001-03-29 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0370465 Medline TA: Am Heart J Country: United States |
Other Details:
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Languages: eng Pagination: S22-5 Citation Subset: AIM; IM |
Affiliation:
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University Hospital of Groningen, The Netherlands. G.Amoroso@thorax.azg.nl |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Angioplasty, Transluminal, Percutaneous Coronary* Clinical Trials as Topic Coronary Disease / diagnosis, therapy* Decision Making* Fibrinolytic Agents / therapeutic use Humans Prognosis Severity of Illness Index Thrombolytic Therapy* |
| Chemical | |
Reg. No./Substance:
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0/Fibrinolytic Agents |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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