Document Detail


Drug targeting to choroidal neovascularization.
MedLine Citation:
PMID:  11672877     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Subfoveal choroidal neovascularization (CNV) causes significant visual loss, especially in patients with age-related macular degeneration (AMD). Several pharmaceutical treatments that use anti-angiogenic agents have been tried to inhibit the activity of CNV experimentally and clinically. In general, however, systemically administered drugs may reach not only targeted tissues but also other tissues, resulting in unwanted side effects. Also, to maintain therapeutic levels of the drugs in targeted tissues, frequent administration for an extended period of time is required. To solve these problems, drug delivery systems targeted to the CNV are being developed. Anatomic characteristics of CNV tissues resemble those of tumor vasculature, exhibiting enhanced permeability and retention effect. Drug targeting to CNV may be feasible in the same manner as it is to tumors. In this review, we describe two approaches of drug targeting to CNV: passive targeting and active targeting.
Authors:
H Kimura; T Yasukawa; Y Tabata; Y Ogura
Related Documents :
11358337 - Evaluation of the alpha2c-adrenoceptor as a neuropsychiatric drug target studies in tra...
19451287 - Identifying exposure targets for treatment of staphylococcal pneumonia with ceftobiprole.
19413457 - Targeted delivery of thrombolytic agents: role of integrin receptors.
20201747 - Emerging drugs for chronic myeloid leukemia.
11844707 - New indene-derivatives with anti-proliferative properties.
2744907 - Motor effects of locally administered pinaverium bromide in the sigmoid tract of patien...
Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Advanced drug delivery reviews     Volume:  52     ISSN:  0169-409X     ISO Abbreviation:  Adv. Drug Deliv. Rev.     Publication Date:  2001 Oct 
Date Detail:
Created Date:  2001-10-23     Completed Date:  2001-12-07     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8710523     Medline TA:  Adv Drug Deliv Rev     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  79-91     Citation Subset:  IM    
Affiliation:
Department of Ophthalmology, Nagoya City University Medical School, Mizuho-ku, Nagoya, 4678601, Aichi, Japan. hkimura@med.nagoya-cu.ac.jp
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Animals
Antibodies, Monoclonal / therapeutic use
Antigens, CD
Choroidal Neovascularization / drug therapy*
Cyclohexanes
Drug Delivery Systems*
Humans
Immunoconjugates / therapeutic use
Permeability
Polyvinyl Alcohol / administration & dosage
Receptors, Cell Surface
Sesquiterpenes / administration & dosage
Vascular Cell Adhesion Molecule-1 / analysis,  immunology
Chemical
Reg. No./Substance:
0/Antibodies, Monoclonal; 0/Antigens, CD; 0/Cyclohexanes; 0/ENG protein, human; 0/Immunoconjugates; 0/Receptors, Cell Surface; 0/Sesquiterpenes; 0/Vascular Cell Adhesion Molecule-1; 129298-91-5/O-(chloroacetylcarbamoyl)fumagillol; 9002-89-5/Polyvinyl Alcohol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Photosensitizer delivery for photodynamic therapy of choroidal neovascularization.
Next Document:  7-Hydroxy-2-substituted-4-H-1-benzopyran-4-one derivatives as aldose reductase inhibitors: a SAR stu...