| Drug targeting: learning from toxin entry and trafficking in mammalian cells. | |
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MedLine Citation:
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PMID: 20047149 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A significant number of therapeutic targets reside inside cells and intracellular organelles. Therapeutics therefore must be able to gain access to cellular compartments, and be able to interact specifically with a given molecule to exert a desired effect. Many naturally occurring toxins perform such targeting with apparent ease, making them excellent paradigms for the delivery of therapeutics to the cell interior. By studying the mechanisms of cell entry, trafficking and modes of toxicity of these model delivery vectors, researchers can decipher how cells transport both endogenous molecules and exogenously applied therapeutics inside cells. Perhaps more importantly, the exploitation of cell binding and trafficking motifs could allow a therapeutic to target specifically, traffic within and escape from cellular compartments; in addition, toxic domains can be used to disrupt cell function specifically for therapeutic purposes. This review provides an overview of recent developments in the understanding of toxin targeting and trafficking, and discusses how these developments could result in opportunities for the design of more specific and efficient systems for therapeutic targeting. |
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Authors:
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Robert A Spooner; Peter Watson |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: Current opinion in drug discovery & development Volume: 13 ISSN: 2040-3437 ISO Abbreviation: Curr Opin Drug Discov Devel Publication Date: 2010 Jan |
Date Detail:
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Created Date: 2010-01-04 Completed Date: 2010-03-01 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100887519 Medline TA: Curr Opin Drug Discov Devel Country: England |
Other Details:
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Languages: eng Pagination: 86-95 Citation Subset: IM |
Affiliation:
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Cardiff University, School of Biosciences, Museum Avenue, Cardiff, CF10 3AX, UK. R.A.Spooner@warwick.ac.uk |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cells / metabolism*, ultrastructure Drug Delivery Systems* Endoplasmic Reticulum / metabolism Humans Models, Biological Nanoparticles Plasma / metabolism Protein Transport / drug effects, physiology Small Molecule Libraries Toxins, Biological / metabolism* |
| Grant Support | |
ID/Acronym/Agency:
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080566Z/06/Z//Wellcome Trust |
| Chemical | |
Reg. No./Substance:
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0/Small Molecule Libraries; 0/Toxins, Biological |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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