| Drug-target network and polypharmacology studies of a Traditional Chinese Medicine for type II diabetes mellitus. | |
| | |
MedLine Citation:
|
PMID: 22000800 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
|
Many Traditional Chinese Medicines (TCMs) are effective to relieve complicated diseases such as type II diabetes mellitus (T2DM). In this work, molecular docking and network analysis were employed to elucidate the action mechanism of a medical composition which had clinical efficacy for T2DM. We found that multiple active compounds contained in this medical composition would target multiple proteins related to T2DM and the biological network would be shifted. We predicted the key players in the medical composition and some of them have been reported in literature. Meanwhile, several compounds such as Rheidin A, Rheidin C, Sennoside C, procyanidin C1 and Dihydrobaicalin were notable although no one have reported their pharmacological activity against T2DM. The association between active compounds, target proteins and other diseases was also discussed. |
| | |
Authors:
|
Jiangyong Gu; Hu Zhang; Lirong Chen; Shun Xu; Gu Yuan; Xiaojie Xu |
Publication Detail:
|
Type: Journal Article Date: 2011-07-20 |
Journal Detail:
|
Title: Computational biology and chemistry Volume: 35 ISSN: 1476-928X ISO Abbreviation: Comput Biol Chem Publication Date: 2011 Oct |
Date Detail:
|
Created Date: 2011-10-17 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 101157394 Medline TA: Comput Biol Chem Country: England |
Other Details:
|
Languages: eng Pagination: 293-7 Citation Subset: IM |
Copyright Information:
|
Copyright © 2011 Elsevier Ltd. All rights reserved. |
Affiliation:
|
Beijing National Laboratory for Molecular Sciences, State Key Lab of Rare Earth Material Chemistry and Applications, College of Chemistry and Molecular Engineering, Peking University, Beijing 100871, PR China. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Reconstruction and crosstalk of protein-protein interaction networks of Wnt and Hedgehog signaling i...
Next Document: A degree-distribution based hierarchical agglomerative clustering algorithm for protein complexes id...