| Drug-target identification in Drosophila cells: combining high-throughout RNAi and small-molecule screens. | |
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MedLine Citation:
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PMID: 17198970 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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RNA interference (RNAi) and small-molecule approaches are synergistic on multiple levels, from technology and high-throughput screen development to target identification and functional studies. Here, we describe the RNAi screening platform that we have established and made available to the community through the Drosophila RNAi Screening Center at Harvard Medical School. We then illustrate how the combination of RNAi and small-molecule HTS can lead to effective identification of targets in drug discovery. |
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Authors:
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Norbert Perrimon; Adam Friedman; Bernard Mathey-Prevot; Ulrike S Eggert |
Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review Date: 2006-10-30 |
Journal Detail:
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Title: Drug discovery today Volume: 12 ISSN: 1359-6446 ISO Abbreviation: Drug Discov. Today Publication Date: 2007 Jan |
Date Detail:
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Created Date: 2007-01-02 Completed Date: 2007-04-16 Revised Date: 2007-12-03 |
Medline Journal Info:
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Nlm Unique ID: 9604391 Medline TA: Drug Discov Today Country: England |
Other Details:
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Languages: eng Pagination: 28-33 Citation Subset: IM |
Affiliation:
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Department of Genetics, Howard Hughes Medical Institute, Harvard Medical School, Boston, MA 02115, USA. perrimon@receptor.med.harvard.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Drosophila / cytology, genetics Drug Delivery Systems / methods* Drug Design Drug Evaluation, Preclinical / methods* RNA Interference* RNA, Small Interfering / genetics |
| Grant Support | |
ID/Acronym/Agency:
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R01GM067761/GM/NIGMS NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/RNA, Small Interfering |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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