| Drug-resistant tuberculosis and pregnancy: treatment outcomes of 38 cases in Lima, Peru. | |
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MedLine Citation:
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PMID: 19361302 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Multidrug-resistant tuberculosis (MDR-TB) disproportionately affects young adults, including women of childbearing age; however, treatment of MDR-TB during pregnancy is still controversial. This study looks at the treatment and pregnancy outcomes in a cohort of women who were treated for MDR-TB during pregnancy during a period of 10 years. METHODS: A retrospective case study was performed using a standardized data collection form and data from 3 ranked sources of patient records. All 38 participants were treated during pregnancy with individualized regimens that included second-line TB medications. We examined the frequency of favorable and adverse outcomes with regard to disease and pregnancy. RESULTS: After completion of MDR-TB treatment, 61% of the women were cured, 13% had died, 13% had defaulted, 5% remained in treatment, and 5% had experienced treatment failure. Four of the women experienced clinical deterioration of TB during pregnancy. Five of the pregnancies terminated in spontaneous abortions, and 1 child was stillborn. Among the living newborns, 3 were born with low birth weight, 1 was born prematurely, and 1 had fetal distress. CONCLUSIONS: The rates of success in treating MDR-TB in our cohort are comparable to those of other MDR-TB treatment programs in Peru. The birth outcomes of our cohort are similar to those among the general Peru population. Therefore, we advocate that a woman should be given the option to continue treatment of MDR-TB rather than terminating pregnancy or discontinuing MDR-TB treatment. |
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Authors:
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Eda Palacios; Rebecca Dallman; Maribel Muñoz; Rocio Hurtado; Katiuska Chalco; Dalia Guerra; Lorena Mestanza; Karim Llaro; Cesar Bonilla; Peter Drobac; Jaime Bayona; Melissa Lygizos; Holly Anger; Sonya Shin |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America Volume: 48 ISSN: 1537-6591 ISO Abbreviation: Clin. Infect. Dis. Publication Date: 2009 May |
Date Detail:
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Created Date: 2009-04-20 Completed Date: 2009-05-18 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9203213 Medline TA: Clin Infect Dis Country: United States |
Other Details:
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Languages: eng Pagination: 1413-9 Citation Subset: IM |
Affiliation:
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Socios En Salud, Sucursal Peru, Carabayllo, Lima, Peru. epalacios_ses@pih.org |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Animals Antitubercular Agents / therapeutic use* Female Humans Infant, Newborn Middle Aged Peru Pregnancy Pregnancy Complications, Infectious / drug therapy* Retrospective Studies Treatment Outcome Tuberculosis, Multidrug-Resistant / drug therapy* Young Adult |
| Chemical | |
Reg. No./Substance:
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0/Antitubercular Agents |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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