Document Detail


Drug-resistant tuberculosis and pregnancy: treatment outcomes of 38 cases in Lima, Peru.
MedLine Citation:
PMID:  19361302     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Multidrug-resistant tuberculosis (MDR-TB) disproportionately affects young adults, including women of childbearing age; however, treatment of MDR-TB during pregnancy is still controversial. This study looks at the treatment and pregnancy outcomes in a cohort of women who were treated for MDR-TB during pregnancy during a period of 10 years. METHODS: A retrospective case study was performed using a standardized data collection form and data from 3 ranked sources of patient records. All 38 participants were treated during pregnancy with individualized regimens that included second-line TB medications. We examined the frequency of favorable and adverse outcomes with regard to disease and pregnancy. RESULTS: After completion of MDR-TB treatment, 61% of the women were cured, 13% had died, 13% had defaulted, 5% remained in treatment, and 5% had experienced treatment failure. Four of the women experienced clinical deterioration of TB during pregnancy. Five of the pregnancies terminated in spontaneous abortions, and 1 child was stillborn. Among the living newborns, 3 were born with low birth weight, 1 was born prematurely, and 1 had fetal distress. CONCLUSIONS: The rates of success in treating MDR-TB in our cohort are comparable to those of other MDR-TB treatment programs in Peru. The birth outcomes of our cohort are similar to those among the general Peru population. Therefore, we advocate that a woman should be given the option to continue treatment of MDR-TB rather than terminating pregnancy or discontinuing MDR-TB treatment.
Authors:
Eda Palacios; Rebecca Dallman; Maribel Muñoz; Rocio Hurtado; Katiuska Chalco; Dalia Guerra; Lorena Mestanza; Karim Llaro; Cesar Bonilla; Peter Drobac; Jaime Bayona; Melissa Lygizos; Holly Anger; Sonya Shin
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Clinical infectious diseases : an official publication of the Infectious Diseases Society of America     Volume:  48     ISSN:  1537-6591     ISO Abbreviation:  Clin. Infect. Dis.     Publication Date:  2009 May 
Date Detail:
Created Date:  2009-04-20     Completed Date:  2009-05-18     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9203213     Medline TA:  Clin Infect Dis     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1413-9     Citation Subset:  IM    
Affiliation:
Socios En Salud, Sucursal Peru, Carabayllo, Lima, Peru. epalacios_ses@pih.org
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Animals
Antitubercular Agents / therapeutic use*
Female
Humans
Infant, Newborn
Middle Aged
Peru
Pregnancy
Pregnancy Complications, Infectious / drug therapy*
Retrospective Studies
Treatment Outcome
Tuberculosis, Multidrug-Resistant / drug therapy*
Young Adult
Chemical
Reg. No./Substance:
0/Antitubercular Agents

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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