Document Detail

Drug resistance to topoisomerase II inhibitors.
MedLine Citation:
PMID:  9615864     Owner:  NLM     Status:  MEDLINE    
We describe in this review the mechanisms of resistance to topoisomerase II inhibitors that have been identified in cell lines rendered resistant to drugs. They concern especially both quantitative and qualitative alterations of topoisomerase II, leading to drug insensitivity of the cells. Expression and activity of topoisomerase II have also been studied in a number of tumor specimens originating from patients, but the role of topoisomerase II alterations in drug resistance in the clinical setting has not yet been firmly established. It would be worthwhile, however, to develop predictive assays for drug activity in human cancers, based upon the topoisomerase II status of tumor samples.
J Robert; A K Larsen
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Biochimie     Volume:  80     ISSN:  0300-9084     ISO Abbreviation:  Biochimie     Publication Date:  1998 Mar 
Date Detail:
Created Date:  1998-08-07     Completed Date:  1998-08-07     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  1264604     Medline TA:  Biochimie     Country:  FRANCE    
Other Details:
Languages:  eng     Pagination:  247-54     Citation Subset:  IM    
Institut Bergonié et Université Victor Segalen Bordeaux, France.
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MeSH Terms
DNA Topoisomerases, Type II / antagonists & inhibitors*
Drug Resistance, Multiple
Drug Resistance, Neoplasm*
Enzyme Inhibitors / pharmacology*
Tumor Cells, Cultured
Reg. No./Substance:
0/Enzyme Inhibitors; EC Topoisomerases, Type II

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