| Drug resistance to topoisomerase II inhibitors. | |
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MedLine Citation:
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PMID: 9615864 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We describe in this review the mechanisms of resistance to topoisomerase II inhibitors that have been identified in cell lines rendered resistant to drugs. They concern especially both quantitative and qualitative alterations of topoisomerase II, leading to drug insensitivity of the cells. Expression and activity of topoisomerase II have also been studied in a number of tumor specimens originating from patients, but the role of topoisomerase II alterations in drug resistance in the clinical setting has not yet been firmly established. It would be worthwhile, however, to develop predictive assays for drug activity in human cancers, based upon the topoisomerase II status of tumor samples. |
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Authors:
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J Robert; A K Larsen |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Biochimie Volume: 80 ISSN: 0300-9084 ISO Abbreviation: Biochimie Publication Date: 1998 Mar |
Date Detail:
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Created Date: 1998-08-07 Completed Date: 1998-08-07 Revised Date: 2005-11-16 |
Medline Journal Info:
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Nlm Unique ID: 1264604 Medline TA: Biochimie Country: FRANCE |
Other Details:
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Languages: eng Pagination: 247-54 Citation Subset: IM |
Affiliation:
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Institut Bergonié et Université Victor Segalen Bordeaux, France. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals DNA Topoisomerases, Type II / antagonists & inhibitors* Drug Resistance, Multiple Drug Resistance, Neoplasm* Enzyme Inhibitors / pharmacology* Humans Tumor Cells, Cultured |
| Chemical | |
Reg. No./Substance:
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0/Enzyme Inhibitors; EC 5.99.1.3/DNA Topoisomerases, Type II |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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