Document Detail

Drug resistance among previously treated tuberculosis patients, a brief report.
MedLine Citation:
PMID:  6767427     Owner:  NLM     Status:  MEDLINE    
The choice of an appropriate chemotherapeutic regimen for the treatment of tuberculosis is more difficult if the patient has been treated for tuberculosis in the past. This study was undertaken to determine drug-resistance rates among patients previously treated with isoniazid (INH), streptomycin (SM), and/or paraaminosalicylic acid (PAS). The study population consisted of 4,017 patients for whom the length and type of previous therapy was known. Forty-one per cent of these patients were found to be excreting organisms resistant to 1 or more of the following 3 drugs: INH, SM, and PAS. Resistance to INH was encountered most (36.8%), followed by resistance to SM (19.2%), and resistance to PAS (17.2%). Resistance rates were considerably higher among the 1,168 patients who had previously received monotherapy (60%) than among those who had never received single-drug therapy (33%). In general, the percentage of patients excreting resistant organisms increased with increasing duration of the previous therapy. The implications of these findings for the design of retreatment regimens are discussed.
H D Costello; G J Caras; D E Snider
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The American review of respiratory disease     Volume:  121     ISSN:  0003-0805     ISO Abbreviation:  Am. Rev. Respir. Dis.     Publication Date:  1980 Feb 
Date Detail:
Created Date:  1980-05-30     Completed Date:  1980-05-30     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  0370523     Medline TA:  Am Rev Respir Dis     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  313-6     Citation Subset:  AIM; IM    
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MeSH Terms
Aminosalicylic Acid / therapeutic use*
Aminosalicylic Acids / therapeutic use*
Drug Resistance, Microbial
Drug Therapy, Combination
Isoniazid / therapeutic use*
Mycobacterium tuberculosis / drug effects*
Sputum / microbiology
Streptomycin / therapeutic use*
Time Factors
Tuberculosis, Pulmonary / drug therapy*,  microbiology
Reg. No./Substance:
0/Aminosalicylic Acids; 54-85-3/Isoniazid; 57-92-1/Streptomycin; 65-49-6/Aminosalicylic Acid

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