| Drug resistance among previously treated tuberculosis patients, a brief report. | |
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MedLine Citation:
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PMID: 6767427 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The choice of an appropriate chemotherapeutic regimen for the treatment of tuberculosis is more difficult if the patient has been treated for tuberculosis in the past. This study was undertaken to determine drug-resistance rates among patients previously treated with isoniazid (INH), streptomycin (SM), and/or paraaminosalicylic acid (PAS). The study population consisted of 4,017 patients for whom the length and type of previous therapy was known. Forty-one per cent of these patients were found to be excreting organisms resistant to 1 or more of the following 3 drugs: INH, SM, and PAS. Resistance to INH was encountered most (36.8%), followed by resistance to SM (19.2%), and resistance to PAS (17.2%). Resistance rates were considerably higher among the 1,168 patients who had previously received monotherapy (60%) than among those who had never received single-drug therapy (33%). In general, the percentage of patients excreting resistant organisms increased with increasing duration of the previous therapy. The implications of these findings for the design of retreatment regimens are discussed. |
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Authors:
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H D Costello; G J Caras; D E Snider |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: The American review of respiratory disease Volume: 121 ISSN: 0003-0805 ISO Abbreviation: Am. Rev. Respir. Dis. Publication Date: 1980 Feb |
Date Detail:
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Created Date: 1980-05-30 Completed Date: 1980-05-30 Revised Date: 2009-11-19 |
Medline Journal Info:
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Nlm Unique ID: 0370523 Medline TA: Am Rev Respir Dis Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 313-6 Citation Subset: AIM; IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aminosalicylic Acid
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therapeutic use* Aminosalicylic Acids / therapeutic use* Drug Resistance, Microbial Drug Therapy, Combination Humans Isoniazid / therapeutic use* Mycobacterium tuberculosis / drug effects* Sputum / microbiology Streptomycin / therapeutic use* Time Factors Tuberculosis, Pulmonary / drug therapy*, microbiology |
| Chemical | |
Reg. No./Substance:
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0/Aminosalicylic Acids; 54-85-3/Isoniazid; 57-92-1/Streptomycin; 65-49-6/Aminosalicylic Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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