Document Detail


Drug repositioning by structure-based virtual screening.
MedLine Citation:
PMID:  23288298     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Approved drugs have favourable or validated pharmacokinetic properties and toxicological profiles, and the repositioning of existing drugs for new indications can potentially avoid expensive costs associated with early-stage testing of the hit compounds. In recent years, technological advances in virtual screening methodologies have allowed medicinal chemists to rapidly screen drug libraries for therapeutic activity against new biomolecular targets in a cost-effective manner. This review article outlines the basic principles and recent advances in structure-based virtual screening and highlights the powerful synergy of in silico techniques in drug repositioning as demonstrated in several recent reports.
Authors:
Dik-Lung Ma; Daniel Shiu-Hin Chan; Chung-Hang Leung
Related Documents :
23064238 - Systematic identification of synergistic drug pairs targeting hiv.
12853768 - Viability and safety of combination drug therapies for erectile dysfunction.
23861568 - In silico analysis of escherichia coli polyphosphate kinase (ppk) as a novel antimicrob...
2030098 - The hydrolysis of lucerne cell-wall monosaccharide components by monocultures or pair c...
3923078 - Modification of the electrophysiologic matrix by antiarrhythmic drugs.
20799138 - Asthma & copd--iqpc's second conference.
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-1-4
Journal Detail:
Title:  Chemical Society reviews     Volume:  -     ISSN:  1460-4744     ISO Abbreviation:  Chem Soc Rev     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-1-4     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0335405     Medline TA:  Chem Soc Rev     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Department of Chemistry, Hong Kong Baptist University, Kowloon Tong, Hong Kong, China. edmondma@hkbu.edu.hk.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Long-term effects of an occupational health guideline on employees' body weight-related outcomes, ca...
Next Document:  LAW, REPRODUCTION, AND DISABILITY: FATALLY 'HANDICAPPED'?