| Drug release from lipid-based implants: elucidation of the underlying mass transport mechanisms. | |
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MedLine Citation:
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PMID: 16503388 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The aim of this study was to better understand the mass transport mechanisms involved in the control of drug release from lipid-based implants. Different types of triglyceride-based cylinders were prepared by compression. Glycerol-trilaurate, -trimyristate, -tripalmitate and -tristearate were used as model lipids, lysozyme and pyranine as model drugs. The effects of several formulation and processing parameters on the resulting drug release kinetics in phosphate buffer pH 7.4 were studied and the obtained results analyzed using Fick's second law of diffusion. Interestingly, lysozyme release from implants prepared by compression of a lyophilized emulsion (containing dissolved drug and lipid) was found to be purely diffusion-controlled, irrespective of the type of triglyceride. In contrast, the dominating release mechanism depended on the type of lipid in the case of pyranine-loaded implants prepared by compression of a lyophilized lipid-drug solution: with glycerol-trilaurate and -tristearate the systems were found to be purely diffusion-controlled, whereas also other mass transport phenomena are of importance in glycerol-trimyristate and -tripalmitate-based devices. Similarly, changes in the size of the compressed lipid-drug particles, drug loading and compression force significantly affected the underlying release mechanisms. The addition of a drug-free, poly(lactic-co-glycolic acid) (PLGA)-based coating around the implants delayed the onset of pyranine release for about 20 days. Interestingly, the subsequent drug release was purely diffusion-controlled, irrespective of the type of triglyceride. Also the addition of different amounts (and particle size fractions) of saccharose to pyranine-loaded implants led to purely diffusion-controlled drug release. |
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Authors:
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C Guse; S Koennings; F Kreye; F Siepmann; A Goepferich; J Siepmann |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2006-02-28 |
Journal Detail:
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Title: International journal of pharmaceutics Volume: 314 ISSN: 0378-5173 ISO Abbreviation: Int J Pharm Publication Date: 2006 May |
Date Detail:
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Created Date: 2006-05-08 Completed Date: 2007-08-06 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7804127 Medline TA: Int J Pharm Country: Netherlands |
Other Details:
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Languages: eng Pagination: 137-44 Citation Subset: IM |
Affiliation:
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College of Pharmacy, University of Regensburg, Universitaetsstr. 31, 93040 Regensburg, Germany. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Arylsulfonates
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chemistry*,
metabolism Biological Transport Chemistry, Pharmaceutical Diffusion Drug Carriers* Drug Implants* Kinetics Lactic Acid / chemistry Lipids / chemistry* Models, Chemical Muramidase / chemistry*, metabolism Particle Size Polyglycolic Acid / chemistry Polymers / chemistry Porosity Solubility Sucrose / chemistry Technology, Pharmaceutical / methods Triglycerides / chemistry |
| Chemical | |
Reg. No./Substance:
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0/Arylsulfonates; 0/Drug Carriers; 0/Drug Implants; 0/Lipids; 0/Polymers; 0/Triglycerides; 0/polylactic acid-polyglycolic acid copolymer; 26009-03-0/Polyglycolic Acid; 50-21-5/Lactic Acid; 57-50-1/Sucrose; 6358-69-6/pyranine; EC 3.2.1.17/Muramidase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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