Document Detail

Drug-related Churg-Strauss syndrome?
MedLine Citation:
PMID:  9838966     Owner:  NLM     Status:  MEDLINE    
Churg-Strauss syndrome (CSS) is a rare disease belonging to the group of necrotizing vasculitides affecting medium and small vessels, classified together with Wegener granulomatosis and microscopic polyarteritis. The literature is reviewed concerning vasculitides associated with drug use, focusing on CSS. A representative case of CSS is reported, in whom the possibility could not be excluded that oestrogen replacement therapy contributed to the onset of CSS. The case of a 56-year-old female patient is presented who had a history of allergic rhinitis and steroid-dependent asthma for years. To prevent postmenopausal complaints and further loss of bone density, she received oestrogen replacement therapy. After three months of hormone therapy, signs of CSS appeared. Oestrogen administration (1 mg norethisterone acetate, 1 mg oestriol and 2 mg oestradiol daily) was stopped. The diagnosis was confirmed by the clinical appearance, laboratory tests and tissue biopsies. The patient received corticosteroids and cyclophosphamide treatment and subsequently the eosinophil count returned to normal within two weeks and her condition improved significantly.
A Somogyi; G Müzes; J Molnár; Z Tulassay
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Publication Detail:
Type:  Case Reports; Journal Article; Review    
Journal Detail:
Title:  Adverse drug reactions and toxicological reviews     Volume:  17     ISSN:  0964-198X     ISO Abbreviation:  Adverse Drug React Toxicol Rev     Publication Date:    1998 Jun-Sep
Date Detail:
Created Date:  1999-03-09     Completed Date:  1999-03-09     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  9109474     Medline TA:  Adverse Drug React Toxicol Rev     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  63-74     Citation Subset:  IM    
Semmelweis University Medical School, 2nd Department of Medicine, Szentkirályi u., Hungary.
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MeSH Terms
Churg-Strauss Syndrome / chemically induced*,  diagnosis,  drug therapy
Cyclophosphamide / therapeutic use*
Diagnosis, Differential
Estrogens / adverse effects*
Hormone Replacement Therapy / adverse effects*
Middle Aged
Reg. No./Substance:
0/Estrogens; 50-18-0/Cyclophosphamide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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