Document Detail

Drug prophylaxis for arterial thromboembolism--1981.
MedLine Citation:
PMID:  7029018     Owner:  NLM     Status:  MEDLINE    
Recent multicenter clinical trials using platelet-suppressive agents for the secondary prevention of myocardial infarction have yielded inconclusive results, although some of the data suggest possible benefits. For transient ischemic attacks, after carotid artery surgery has been eliminated as an option, aspirin is the drug of choice for men; for women, and for men in whom aspirin fails, warfarin sodium should be considered. Warfarin is indicated after insertion of cardiac prosthetic disk valves, and if systemic emboli occur, dipyridamole should be added. Patients with atrial fibrillation should be treated prophylactically with coumarin agents, but only if underlying organic heart disease is demonstrable.
S Wessler
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Publication Detail:
Type:  Clinical Trial; Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  JAMA     Volume:  246     ISSN:  0098-7484     ISO Abbreviation:  JAMA     Publication Date:  1981 Nov 
Date Detail:
Created Date:  1982-01-28     Completed Date:  1982-01-28     Revised Date:  2014-09-17    
Medline Journal Info:
Nlm Unique ID:  7501160     Medline TA:  JAMA     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  2484-7     Citation Subset:  AIM; IM    
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MeSH Terms
Aspirin / therapeutic use*
Blood Platelets / drug effects
Cerebrovascular Disorders / prevention & control
Clinical Trials as Topic
Coumarins / therapeutic use
Decision Making
Hemorrhage / prevention & control
Heparin / therapeutic use
Myocardial Infarction / prevention & control
Sex Factors
Thromboembolism / prevention & control*
Warfarin / adverse effects,  therapeutic use*
Grant Support
Reg. No./Substance:
0/Coumarins; 5Q7ZVV76EI/Warfarin; 9005-49-6/Heparin; R16CO5Y76E/Aspirin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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