Document Detail


Drug-nitrite interactions: species and sex differences in the formation of dimethylnitrosamine and its effects on the hepatic enzyme activities.
MedLine Citation:
PMID:  288343     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Aminopyrine interacted with sodium nitrite in the stomachs of rats and guinea pigs forming dimethylnitrosamine, which affected the hepatic microsomal drug metabolism and certain hepatic enzyme activities. Sex and species differences in changes in the enzyme activities were observed after single or simultaneous administration of aminopyrine and sodium nitrite. A protective effect on dimethylnitrosamine formation with ascorbic acid and alpha-tocopherol was observed. The in vivo formation of dimethylnitrosamine by several antibiotics and an antihistaminic drug with tertiary amino group was also examined.
Authors:
Y Omori; A Takahashi; Y Ohno; H Ishiwata; A Tanimura
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Archives of toxicology. Supplement. = Archiv für Toxikologie. Supplement     Volume:  -     ISSN:  0171-9750     ISO Abbreviation:  Arch. Toxicol. Suppl.     Publication Date:  1979  
Date Detail:
Created Date:  1979-09-25     Completed Date:  1979-09-25     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  7802567     Medline TA:  Arch Toxicol Suppl     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  349-54     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Aminopyrine / metabolism
Animals
Dimethylnitrosamine / metabolism*
Female
Guinea Pigs
Hexobarbital / pharmacology
Liver / enzymology*
Male
Nitrites / metabolism*,  pharmacology
Nitrosamines / metabolism*
Rats
Sex Factors
Sleep / drug effects
Species Specificity
Stomach / metabolism
Time Factors
Chemical
Reg. No./Substance:
0/Nitrites; 0/Nitrosamines; 56-29-1/Hexobarbital; 58-15-1/Aminopyrine; 62-75-9/Dimethylnitrosamine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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