Document Detail


Drug monitoring of lamotrigine and oxcarbazepine combination during pregnancy.
MedLine Citation:
PMID:  21204816     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Little is known about pregnancy-induced alterations in the pharmacokinetics of the newer antiepileptic drugs, especially when used in combinations. Two women receiving combination therapy of lamotrigine (LTG) and oxcarbazepine (OXC) were followed prospectively during pregnancy and puerperium. Steady-state concentrations of LTG and the active metabolite of OXC, 10-hydroxycarbazepine (MHD), were measured at regular intervals using a dried blood spot method, and clearances were calculated. A strong effect of pregnancy on the clearance of both LTG and MHD was seen. An increase in seizure frequency occurred in both women. This stresses the importance of therapeutic drug monitoring of LTG and MHD during pregnancy. In case of breakthrough seizures or increased seizure frequency, dosage adjustment of both drugs may be required.
Authors:
Ilse Wegner; Peter Edelbroek; Gerrit-Jan de Haan; Dick Lindhout; Josemir W Sander
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Publication Detail:
Type:  Case Reports; Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-11-03
Journal Detail:
Title:  Epilepsia     Volume:  51     ISSN:  1528-1167     ISO Abbreviation:  Epilepsia     Publication Date:  2010 Dec 
Date Detail:
Created Date:  2011-01-05     Completed Date:  2011-02-14     Revised Date:  2013-08-21    
Medline Journal Info:
Nlm Unique ID:  2983306R     Medline TA:  Epilepsia     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2500-2     Citation Subset:  IM    
Copyright Information:
Wiley Periodicals, Inc. © 2010 International League Against Epilepsy.
Affiliation:
SEIN, Epilepsy Institute in the Netherlands, Zwolle, The Netherlands. iwegner@sein.nl
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MeSH Terms
Descriptor/Qualifier:
Adult
Anticonvulsants / pharmacokinetics*,  therapeutic use
Carbamazepine / analogs & derivatives*,  blood,  metabolism,  pharmacokinetics,  therapeutic use
Dose-Response Relationship, Drug
Drug Monitoring / methods*
Drug Therapy, Combination
Epilepsies, Partial / drug therapy*,  metabolism*
Female
Humans
Metabolic Clearance Rate
Postpartum Period / metabolism
Pregnancy
Pregnancy Complications / drug therapy*,  metabolism
Triazines / pharmacokinetics*,  therapeutic use
Chemical
Reg. No./Substance:
0/10,11-dihydro-10-hydroxycarbamazepine; 0/Anticonvulsants; 0/Triazines; 298-46-4/Carbamazepine; U3H27498KS/lamotrigine; VZI5B1W380/oxcarbazepine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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