Document Detail

Drug-mediated immunogenic changes of virus-induced leukemia in vivo.
MedLine Citation:
PMID:  1260759     Owner:  NLM     Status:  MEDLINE    
LSTRA and RBL-5 lymphomas induced by Moloney and Rauscher leukemia viruses, respectively, were used to determine whether antigenically altered tumors induced by 5-(3,3-dimethyl-1-triazeno)-imidazole-4-carboxamide in vivo would retain their original antigenic properties and/or have new antigenic properties. The tumors became highly immunogenic in the syngeneic hosts after 4 to 8 transplant generations with drug treatment. Syngeneic mice could be protected against challenge with the parental tumor by presensitization with the drug-altered sublines while unrelated tumor lines were incapable of protecting them. The drug-altered subline of LSTRA was used for treatment of the LSTRA in conjunction with chemotherapy, and this immunochemotherapy produced significant increases in number of survivors and increases in median survival time compared to either treatment alone. Tolerance studies indicated that there are novel antigens and parental tumor antigens associated with the drug-treated sublines.
D P Houchens; E Bonmassar; M R Gaston; M Kende; A Goldin
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Cancer research     Volume:  36     ISSN:  0008-5472     ISO Abbreviation:  Cancer Res.     Publication Date:  1976 Apr 
Date Detail:
Created Date:  1976-07-06     Completed Date:  1976-07-06     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  2984705R     Medline TA:  Cancer Res     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1347-52     Citation Subset:  IM    
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MeSH Terms
Antigens, Neoplasm / analysis*
Carmustine / therapeutic use
Cell Line
Cross Reactions
Cyclophosphamide / therapeutic use
Leukemia, Experimental / drug therapy,  immunology*
Mice, Inbred BALB C
Mice, Inbred C57BL
Mice, Nude
Moloney murine leukemia virus
Neoplasm Transplantation
Radiation Effects
Rauscher Virus
Transplantation, Isogeneic
Reg. No./Substance:
0/Antigens, Neoplasm; 0/Triazenes; 154-93-8/Carmustine; 4342-03-4/Dacarbazine; 50-18-0/Cyclophosphamide

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