| Drug loaded erythrocytes: as novel drug delivery system. | |
| | |
MedLine Citation:
|
PMID: 18220819 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Novel drug delivery systems are one of the widely used delivery systems. In the present scenario, amongst them, "Drug Loaded Erythrocytes" is one of the growing and potential systems for delivery of drugs and enzymes. Erythrocytes are biocompatible, biodegradable, possess long circulation half-life and can be loaded with variety of biologically active substances. Carrier erythrocytes are prepared by collecting blood sample from the organism of interest and separating erythrocytes from plasma. By using various physical and chemical methods the cells are broken and the drug is entrapped into the erythrocytes, finally they are resealed and the resultant carriers are then called "resealed erythrocytes". Surface modification with glutaraldehyde, antibodies, carbohydrates like sialic acid and biotinylation of loaded erythrocytes (biotinylated erythrocytes) is possible to improve their target specificity and to increase their circulation half-life. Upon reinjection the drug loaded erythrocytes serve as slow circulation depots, targets the drug to the reticuloendothelial system (RES), prevents degradation of loaded drug from inactivation by endogenous chemicals, attain steady state concentration of drug and decrease the side-effects of loaded drug. Nowadays, Nanoerythrosomes based drug delivery systems have excellent potential for clinical application. |
| | |
Authors:
|
P D Patel; N Dand; R S Hirlekar; V J Kadam |
Related Documents
:
|
15518929 - Studying biophysical barriers to dna delivery by advanced light microscopy. 15896189 - Optimizing drug delivery systems using systematic "design of experiments." part ii: ret... 19799949 - Chitosan-based hydrogels for controlled, localized drug delivery. 20201739 - From conventional towards new - natural surfactants in drug delivery systems design: cu... 16822229 - Respiratory drug delivery x. boca raton, fl, usa, 24-27 april 2006. 11934349 - Oxybutynin chloride: alterations in drug delivery and improved therapeutic index. 21892879 - Interspecies scaling and prediction of human clearance: comparison of small- and macro-... 16407899 - Direct evidence of astrocytic modulation in the development of rewarding effects induce... 22271809 - Drug-induced vasculitis: a clinical and pathological review. |
Publication Detail:
|
Type: Journal Article; Review |
Journal Detail:
|
Title: Current pharmaceutical design Volume: 14 ISSN: 1873-4286 ISO Abbreviation: Curr. Pharm. Des. Publication Date: 2008 |
Date Detail:
|
Created Date: 2008-01-28 Completed Date: 2008-02-28 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 9602487 Medline TA: Curr Pharm Des Country: Netherlands |
Other Details:
|
Languages: eng Pagination: 63-70 Citation Subset: IM |
Affiliation:
|
Bharati Vidyapeeth's College of Pharmacy, Sector-8, C. B. D. Belapur, Navi-Mumbai-400614, India. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Delayed-Action Preparations Drug Carriers* Drug Delivery Systems* Erythrocytes / chemistry* Half-Life Humans Mononuclear Phagocyte System / metabolism Nanostructures / chemistry |
| Chemical | |
Reg. No./Substance:
|
0/Delayed-Action Preparations; 0/Drug Carriers |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Small molecule complementarity as a source of novel pharmaceutical agents and combination therapies.
Next Document: Intestinal immunomodulation. Role of regulative peptides and promising pharmacological activities.