Document Detail


Drug-loaded electrospun materials in wound-dressing applications and in local cancer treatment.
MedLine Citation:
PMID:  23289491     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
INTRODUCTION: During the last decade, the use of electrospinning for the fabrication of nanofibrous materials loaded with antibacterial agents or anticancer drugs for biomedical applications such as dressing materials for wound treatment and for local cancer treatment has evoked considerable interest. Different drugs can be easily incorporated in electrospun materials and their release profile can be controlled through changes in the fibers morphology, porosity and composition. The large specific surface area of the electrospun materials, the possibility for gradual release and site-specific local delivery of the active compounds lead to cytotoxicity decrease and enhancement of the therapeutic effect of the drugs.
AREAS COVERED: The most recent studies on drug-loaded electrospun mats as materials for wound dressing or local cancer treatment are briefly summarized.
EXPERT OPINION: The possibility for local drug delivery in cancer therapy using electrospun materials allows avoiding the oral or systemic drug application, thus leading to decrease in some deleterious side effects. The recent achievements in the comprehension of the electrospinning, in control over the surface chemical composition of the electrospun materials, and in diversifying the applied approaches and techniques, propound larger prospects for creating new materials for wound dressing and local cancer treatment.
Authors:
Milena Ignatova; Iliya Rashkov; Nevena Manolova
Publication Detail:
Type:  Journal Article; Review     Date:  2013-01-07
Journal Detail:
Title:  Expert opinion on drug delivery     Volume:  10     ISSN:  1744-7593     ISO Abbreviation:  Expert Opin Drug Deliv     Publication Date:  2013 Apr 
Date Detail:
Created Date:  2013-03-15     Completed Date:  2013-05-17     Revised Date:  2013-11-06    
Medline Journal Info:
Nlm Unique ID:  101228421     Medline TA:  Expert Opin Drug Deliv     Country:  England    
Other Details:
Languages:  eng     Pagination:  469-83     Citation Subset:  IM    
Affiliation:
Institute of Polymers, Laboratory of Bioactive Polymers, Bulgarian Academy of Sciences, Acad. G. Bonchev St, bl. 103A, BG-1113 Sofia, Bulgaria.
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MeSH Terms
Descriptor/Qualifier:
Anti-Bacterial Agents / administration & dosage*,  chemistry
Antineoplastic Agents / administration & dosage*,  chemistry
Bandages*
Chemistry, Pharmaceutical
Drug Delivery Systems*
Humans
Nanofibers / chemistry*
Neoplasms / drug therapy*
Porosity
Technology, Pharmaceutical*
Chemical
Reg. No./Substance:
0/Anti-Bacterial Agents; 0/Antineoplastic Agents

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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