| Drug interference on some biochemical parameters of rat cerebral cortex during post-ischemic recovery. | |
| | |
MedLine Citation:
|
PMID: 6778399 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Glycolytic substrates and metabolites (glycogen, glucose, glucose-6-phosphate, pyruvate, lactate), tricarboxylic acid cycle intermediates (citrate, alpha-ketoglutarate, succinate, fumarate, malate), related amino acids (glutamate, glutamine, alanine, gamma-aminobutyrate) and energy mediators (ATP, ADP, AMP, creatine phosphate) were evaluated in the cerebral cortex of rats after 5 min of complete compression ischemia as well as after 3, 15 or 30 min of recirculation following 5 min ischemia. The post-ischemic recovery was studied in control animals or in animals treated (30 min before ischemia and during discovery) by intravenous perfusion of vincamine, theophylline, dihydroergocristine and alanine. Interrelated changes of intermediates of the carbohydrate and the amino acid metabolism have been observed. It is concluded that alanine perfusion induced a partial detour of the lactacid anaerobic process towards the succinate-related alactacid cycle, leading to an increase in the cortical gamma-aminobutyrate content. Vincamine and dihydroergocristine acted in the opposite direction. |
| | |
Authors:
|
G Benzi; E Arrigoni; O Pastoris; S Raimondo; M Dossena; D Fulle; M C Tumminello; R F Villa |
Related Documents
:
|
2876369 - Putative neurotransmitters in three experimental filariasis models. 3818639 - Substrate stereospecificity and active site topography of gamma-aminobutyric acid amino... 19401169 - The effects of chronic repetitive transcranial magnetic stimulation on glutamate and ga... 12396079 - Effects of chronic administration of bilobalide on amino acid levels in mouse brain. 22052719 - Biodegradable polymers derived from amino acids. 3986429 - Antagonism of inhibitory amino acids by the steroid derivative ru5135. 4633349 - Dipicolinic acid location in intact spores of bacillus megaterium. 3372639 - Analysis of amino acids in brain and plasma samples by sensitive gas chromatography-mas... 19951749 - Optimal production of 7,10-dihydroxy-8(e)-hexadecenoic acid from palmitoleic acid by ps... |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Archives internationales de pharmacodynamie et de thérapie Volume: 247 ISSN: 0003-9780 ISO Abbreviation: Arch Int Pharmacodyn Ther Publication Date: 1980 Oct |
Date Detail:
|
Created Date: 1981-02-24 Completed Date: 1981-02-24 Revised Date: 2012-01-12 |
Medline Journal Info:
|
Nlm Unique ID: 0405353 Medline TA: Arch Int Pharmacodyn Ther Country: BELGIUM |
Other Details:
|
Languages: eng Pagination: 198-216 Citation Subset: IM |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Alanine
/
pharmacology Amino Acids / metabolism Animals Brain Ischemia / metabolism* Cerebral Cortex / drug effects*, metabolism Dihydroergotoxine / pharmacology Energy Transfer / drug effects Glycolysis / drug effects Male Rats Theophylline / pharmacology Vincamine / pharmacology |
| Chemical | |
Reg. No./Substance:
|
0/Amino Acids; 11032-41-0/Dihydroergotoxine; 1617-90-9/Vincamine; 56-41-7/Alanine; 58-55-9/Theophylline |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Measurement of inhibin.
Next Document: Effects on 1,3-bis(tetrahydro-2-furanyl)-5-fluoro-2,4-pyrimidinedione(FD-1) on the central nervous s...