Document Detail


Drug interactions with urate excretion in man.
MedLine Citation:
PMID:  3622598     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The effects of pyrazinamide and ampicillin on the uricosuric response to probenecid and benzbromarone were studied in six normal subjects. The amount of uric acid was calculated for the 24 h volume of urine and the urate and creatinine clearances were determined for each of three urinary collection periods in order to calculate the percentage Curate/Ccreatinine. Ampicillin alone caused a significant uricosuria in the 0-2 h (p less than 0.025) and 8-24 h (p less than 0.025) periods. Benzbromarone caused a significant reduction in all the parameters. These observations suggest that high concentrations ampicillin compete with uric acid for reabsorption, but that its delayed uricosuric action can be ascribed to the binding of this dipeptide to a charge-mediated receptor site on the brush border membrane of proximal tubular cells. It would also appear that benzbromarone is secreted by the pyrazinamide-sensitive mechanism for urate secretion as it can cause a paradoxical retention of urate, but leaves the other probenecid-sensitive secretory transport process unoccupied as indicated by the fact that it does not change the kinetics of ampicillin.
Authors:
D K Sommers; H S Schoeman
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  European journal of clinical pharmacology     Volume:  32     ISSN:  0031-6970     ISO Abbreviation:  Eur. J. Clin. Pharmacol.     Publication Date:  1987  
Date Detail:
Created Date:  1987-09-30     Completed Date:  1987-09-30     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  1256165     Medline TA:  Eur J Clin Pharmacol     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  499-502     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adult
Ampicillin / administration & dosage*
Benzbromarone / administration & dosage*
Benzofurans / administration & dosage*
Drug Interactions
Humans
Kidney / metabolism
Kinetics
Male
Probenecid / administration & dosage*
Pyrazinamide / administration & dosage*
Uric Acid / urine*
Chemical
Reg. No./Substance:
0/Benzofurans; 3562-84-3/Benzbromarone; 57-66-9/Probenecid; 69-53-4/Ampicillin; 69-93-2/Uric Acid; 98-96-4/Pyrazinamide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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