Document Detail


Drug interactions with irbesartan.
MedLine Citation:
PMID:  11523726     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Irbesartan is an angiotensin II receptor antagonist indicated for the treatment of patients with hypertension. Although irbesartan does not require biotransformation for its pharmacological activity, it does undergo metabolism via the cytochrome P450 (CYP) 2C9 isoenzyme and negligible metabolism by the CYP3A4 isoenzyme. The long term treatment of patients with hypertension is generally required for effective management of the disease, and the use of concurrent medications is usually inevitable. This paper reviews the drug and food interaction trials involving irbesartan that have been conducted to date. Based on the available literature, no significant interactions have been identified between irbesartan and hydrochlorothiazide, nifedipine, simvastatin, tolbutamide, warfarin, magnesium and aluminum hydroxides, digoxin or food. Fluconazole did increase the steady-state peak plasma concentration (by 19%) and area under the concentration-time curve (by 63%) of irbesartan, but these increases are not likely to be clinically significant. In summary, irbesartan has demonstrated minimal potential for drug or food interactions in trials conducted to date.
Authors:
M R Marino; N N Vachharajani
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Clinical pharmacokinetics     Volume:  40     ISSN:  0312-5963     ISO Abbreviation:  Clin Pharmacokinet     Publication Date:  2001  
Date Detail:
Created Date:  2001-08-28     Completed Date:  2002-01-10     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  7606849     Medline TA:  Clin Pharmacokinet     Country:  New Zealand    
Other Details:
Languages:  eng     Pagination:  605-14     Citation Subset:  IM    
Affiliation:
Bristol-Myers Squibb Pharmaceutical Research Institute, Princeton, New Jersey 18543, USA.
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MeSH Terms
Descriptor/Qualifier:
Antihypertensive Agents / metabolism,  pharmacokinetics,  therapeutic use*
Area Under Curve
Biphenyl Compounds / metabolism,  pharmacokinetics,  therapeutic use*
Drug Interactions*
Food
Half-Life
Humans
Hypertension / drug therapy*
Intestinal Absorption
Randomized Controlled Trials as Topic
Tetrazoles / metabolism,  pharmacokinetics,  therapeutic use*
Chemical
Reg. No./Substance:
0/Antihypertensive Agents; 0/Biphenyl Compounds; 0/Tetrazoles; 138402-11-6/irbesartan

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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