Document Detail

Drug interactions and multiple drug administration.
MedLine Citation:
PMID:  891098     Owner:  NLM     Status:  MEDLINE    
Effects of multiple drug administration on adverse drug reactions were studied in 10,518 patients hospitalized on a general medical service during a five-year period. Nine index drug groups, including analgesic, antacid, antiarrhythmic, antimicrobic, anticoagulant, antihypertensive, anti-inflammatory, diuretic, and sedative-tranquilizer drugs, were selected for study. The average number of adverse drug reactions for the anticoagulant and antihypertensive drug groups was higher (p less than 0.05) than for all other drug groups when classified by the number of drugs being taken concurrently (i.e., 0 to 5, 6 to 10, etc.). The rate of reaction for anticoagulant and antihypertensive drug groups was higher (p less than 0.001) than the rate for other drug groups studied. These data suggest a higher risk of adverse drug reactions for patients receiving multiple drugs. The increased risk may result from drug interactions.
F E May; R B Stewart; L E Cluff
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  Clinical pharmacology and therapeutics     Volume:  22     ISSN:  0009-9236     ISO Abbreviation:  Clin. Pharmacol. Ther.     Publication Date:  1977 Sep 
Date Detail:
Created Date:  1977-10-28     Completed Date:  1977-10-28     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0372741     Medline TA:  Clin Pharmacol Ther     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  322-8     Citation Subset:  AIM; IM    
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MeSH Terms
Analgesics / adverse effects
Antacids / adverse effects
Anti-Arrhythmia Agents / adverse effects
Anti-Infective Agents / adverse effects
Anti-Inflammatory Agents / adverse effects
Anticoagulants / adverse effects
Antihypertensive Agents / adverse effects
Diuretics / adverse effects
Drug Interactions*
Drug Therapy, Combination / adverse effects*
Hypnotics and Sedatives / adverse effects
Tranquilizing Agents / adverse effects
Reg. No./Substance:
0/Analgesics; 0/Antacids; 0/Anti-Arrhythmia Agents; 0/Anti-Infective Agents; 0/Anti-Inflammatory Agents; 0/Anticoagulants; 0/Antihypertensive Agents; 0/Diuretics; 0/Hypnotics and Sedatives; 0/Tranquilizing Agents

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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