Document Detail

Drug interactions in hypertensive patients. Pharmacokinetic, pharmacodynamic and genetic considerations.
MedLine Citation:
PMID:  2182265     Owner:  NLM     Status:  MEDLINE    
Antihypertensive treatment has proven benefits, and the number of patients being treated with these drugs is significant. Hypertensive patients may have other medical illnesses for which they receive medications, and interactions between antihypertensive agents and other drugs is likely. Some of these interactions may lead to undesirable effects or even loss of blood pressure control. However, drug interactions can also be beneficial when 2 antihypertensive drugs with different pharmacological actions are prescribed in combination and with a clear therapeutic objective in mind. Clinicians should be aware of the mechanisms and the consequences of the different types of interaction in hypertensive patients, so that a desired pharmacological response can be achieved with the fewest side effects in the patients.
Y W Lam; A M Shepherd
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Clinical pharmacokinetics     Volume:  18     ISSN:  0312-5963     ISO Abbreviation:  Clin Pharmacokinet     Publication Date:  1990 Apr 
Date Detail:
Created Date:  1990-05-17     Completed Date:  1990-05-17     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  7606849     Medline TA:  Clin Pharmacokinet     Country:  NEW ZEALAND    
Other Details:
Languages:  eng     Pagination:  295-317     Citation Subset:  IM    
Department of Pharmacology, University of Texas Health Science Center, San Antonio.
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MeSH Terms
Antihypertensive Agents / pharmacokinetics*,  pharmacology
Drug Interactions
Drug Therapy, Combination
Hypertension / drug therapy,  genetics,  metabolism*
Reg. No./Substance:
0/Antihypertensive Agents

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