Document Detail

Drug interaction between valproic acid and meropenem: a case report.
MedLine Citation:
PMID:  22435264     Owner:  NLM     Status:  MEDLINE    
Valproic acid and meropenam is commonly co-administrated in neurosurgical patients. Meropenem potentially decreases the valproic acid level, which may cause perioperative seizure. There has been no previous report of drug interaction between valproic acid and meropenem in Thailand. The authors report a patient who faced uncontrolled seizure after co-administrated valproic acid and meropenem. The level of valproic acid was assessed in different times after the administration of meropenem. Rapid decrease of valproic level was detected. However due to the administration of other antiepileptic agents, seizure did not develop. It is important for the physicians to recognize drug interaction between valproic acid and meropenem. Avoiding co-administration of both agents, valproic acid level monitoring and additive of other antiepileptic agents seem to be the appropriate solution.
Wichai Suntimaleeworakul; Suthiporn Patharachayakul; Sarunyou Chusri
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Journal of the Medical Association of Thailand = Chotmaihet thangphaet     Volume:  95     ISSN:  0125-2208     ISO Abbreviation:  J Med Assoc Thai     Publication Date:  2012 Feb 
Date Detail:
Created Date:  2012-03-22     Completed Date:  2012-04-10     Revised Date:  2013-08-21    
Medline Journal Info:
Nlm Unique ID:  7507216     Medline TA:  J Med Assoc Thai     Country:  Thailand    
Other Details:
Languages:  eng     Pagination:  293-5     Citation Subset:  IM    
Department of Pharmacy, Faculty of Pharmacy, Silapakorn University, Nakornpathom, Thailand.
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MeSH Terms
Anti-Bacterial Agents / pharmacokinetics*
Anticonvulsants / blood,  pharmacokinetics*
Drug Interactions
Fructose / administration & dosage,  analogs & derivatives
Thienamycins / pharmacokinetics*
Valproic Acid / blood,  pharmacokinetics*
Reg. No./Substance:
0/Anti-Bacterial Agents; 0/Anticonvulsants; 0/Thienamycins; 0H73WJJ391/topiramate; 30237-26-4/Fructose; 96036-03-2/meropenem; 99-66-1/Valproic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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