Document Detail

Drug insight: aldosterone-receptor antagonists in heart failure--the journey continues.
MedLine Citation:
PMID:  17589427     Owner:  NLM     Status:  MEDLINE    
Aldosterone is an important mediator in the pathogenesis of heart failure, and increased plasma aldosterone levels are associated with a poor prognosis. Aldosterone-receptor blocking drugs can slow the progression of left ventricular remodeling and reduce the occurrence of sudden cardiac death. Two widely publicized clinical trials provide data demonstrating survival benefits with spironolactone and eplerenone in chronic and postinfarction heart failure. The publication of these trials has generated widespread enthusiasm for spironolactone and eplerenone, leading to the more frequent and sometimes unbridled use of these drugs in the medical community. We herein describe the likely mechanisms of action of aldosterone-receptor antagonists, discuss the existing clinical evidence supporting their use, and provide practical advice on their use in the management of patients with heart failure.
Srinivasa R Kalidindi; W H Wilson Tang; Gary S Francis
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Nature clinical practice. Cardiovascular medicine     Volume:  4     ISSN:  1743-4300     ISO Abbreviation:  Nat Clin Pract Cardiovasc Med     Publication Date:  2007 Jul 
Date Detail:
Created Date:  2007-06-25     Completed Date:  2007-06-27     Revised Date:  2013-11-25    
Medline Journal Info:
Nlm Unique ID:  101226507     Medline TA:  Nat Clin Pract Cardiovasc Med     Country:  England    
Other Details:
Languages:  eng     Pagination:  368-78     Citation Subset:  IM    
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MeSH Terms
Aldosterone / physiology
Drug Therapy, Combination
Heart Failure / drug therapy*,  mortality
Hypertension / drug therapy
Kaplan-Meier Estimate
Mineralocorticoid Receptor Antagonists* / contraindications,  therapeutic use*
Practice Guidelines as Topic
Spironolactone / analogs & derivatives,  therapeutic use*
Reg. No./Substance:
0/Mineralocorticoid Receptor Antagonists; 27O7W4T232/Spironolactone; 4964P6T9RB/Aldosterone; 6995V82D0B/eplerenone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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