| Drug insight: aldosterone-receptor antagonists in heart failure--the journey continues. | |
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MedLine Citation:
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PMID: 17589427 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Aldosterone is an important mediator in the pathogenesis of heart failure, and increased plasma aldosterone levels are associated with a poor prognosis. Aldosterone-receptor blocking drugs can slow the progression of left ventricular remodeling and reduce the occurrence of sudden cardiac death. Two widely publicized clinical trials provide data demonstrating survival benefits with spironolactone and eplerenone in chronic and postinfarction heart failure. The publication of these trials has generated widespread enthusiasm for spironolactone and eplerenone, leading to the more frequent and sometimes unbridled use of these drugs in the medical community. We herein describe the likely mechanisms of action of aldosterone-receptor antagonists, discuss the existing clinical evidence supporting their use, and provide practical advice on their use in the management of patients with heart failure. |
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Authors:
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Srinivasa R Kalidindi; W H Wilson Tang; Gary S Francis |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Nature clinical practice. Cardiovascular medicine Volume: 4 ISSN: 1743-4300 ISO Abbreviation: - Publication Date: 2007 Jul |
Date Detail:
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Created Date: 2007-06-25 Completed Date: 2007-06-27 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 101226507 Medline TA: Nat Clin Pract Cardiovasc Med Country: England |
Other Details:
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Languages: eng Pagination: 368-78 Citation Subset: IM |
Affiliation:
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Department of Cardiovascular Medicine, Cleveland Clinic, Cleveland, OH, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aldosterone
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physiology Aldosterone Antagonists / contraindications, therapeutic use* Drug Therapy, Combination Heart Failure / drug therapy*, mortality Humans Hypertension / drug therapy Kaplan-Meiers Estimate Practice Guidelines as Topic Receptors, Aldosterone / antagonists & inhibitors* Spironolactone / analogs & derivatives, therapeutic use* |
| Chemical | |
Reg. No./Substance:
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0/Aldosterone Antagonists; 0/Receptors, Aldosterone; 0/eplerenone; 52-01-7/Spironolactone; 52-39-1/Aldosterone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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