| Drug induction of hepatic glutathione S-transferases in male and female rats*. | |
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MedLine Citation:
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PMID: 808217 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The induction of the glutathione S-transferases by phenobarbital and polycyclic hydrocarbons was studied in male and female rats. Administration of phenobarbital resulted in 60-80% increase in S-aryl and S-aralkyl enzyme specific activities, whereas the S-epoxide and S-alkyl activities were increased by 30-40%. In following the sequence of induction, the former two activities were noted to reach peak activities before an increase in the latter two activities was observed. Both 3-methylcholanthrene and 3,4-benzopyrene were shown toi nduce these four enzymic activities, although without the discrimination between pairs of activities noted with phenobarbital. No change in Km accompanied the increase in Vmax. after induction by drugs, and no change occurred in Ki for sulphobromophthalein inhibition. Significantly lower enzyme specific activities were found for three of the activities studied in female rats but no difference was observed in the S-alkyltransferase activity. However, the proportional increase in the enzymic activities in response to phenobarbital was the same in males and females. These studies demonstrate the drug induction of a group of cytosolic drug-metabolizing enzymes as well as the identification of sex differences in these activities. |
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Authors:
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N Kaplowitz; J Kuhlekamp; G Clifton |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: The Biochemical journal Volume: 146 ISSN: 0264-6021 ISO Abbreviation: Biochem. J. Publication Date: 1975 Feb |
Date Detail:
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Created Date: 1975-11-07 Completed Date: 1975-11-07 Revised Date: 2009-11-18 |
Medline Journal Info:
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Nlm Unique ID: 2984726R Medline TA: Biochem J Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 351-6 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Benzopyrenes / pharmacology Enzyme Induction Female Glutathione Transferase / metabolism Haplorhini Humans Kinetics Liver / drug effects, enzymology* Male Methylcholanthrene / pharmacology Phenobarbital / pharmacology* Polycyclic Compounds / pharmacology* Sex Factors Transferases / metabolism* |
| Chemical | |
Reg. No./Substance:
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0/Benzopyrenes; 0/Polycyclic Compounds; 50-06-6/Phenobarbital; 56-49-5/Methylcholanthrene; EC 2.-/Transferases; EC 2.5.1.18/Glutathione Transferase |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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