Document Detail

Drug induced myopia associated with treatment for gynecological problems.
MedLine Citation:
PMID:  7549443     Owner:  NLM     Status:  MEDLINE    
We present three cases of women who developed acute transient myopia caused by drugs for gynecological problems. One patient was treated with disothiazide for premenstrual edema. The second had acute cystitis and was treated by sulphonamide and the third developed myopia coincident with metronidazole treatment for trichomonas vaginalis. We followed these patients by A scan ultrasonographic ocular measurements, documenting reduction of the anterior chamber depth combined with lens thickening. The ocular and myopic changes cleared up completely on discontinuation of the causative agent. The possible mechanism is thought to be an allergic reaction to the drug.
A Grinbaum; I Ashkenazi; I Avni
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  European journal of ophthalmology     Volume:  5     ISSN:  1120-6721     ISO Abbreviation:  Eur J Ophthalmol     Publication Date:    1995 Apr-Jun
Date Detail:
Created Date:  1995-11-07     Completed Date:  1995-11-07     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  9110772     Medline TA:  Eur J Ophthalmol     Country:  ITALY    
Other Details:
Languages:  eng     Pagination:  136-8     Citation Subset:  IM    
Goldschleger Eye Institute, Chaim Sheba Medical Center, Tel-Hashomer, Israel.
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MeSH Terms
Acute Disease
Anterior Chamber / drug effects,  ultrasonography
Genital Diseases, Female / drug therapy*
Hydrochlorothiazide / adverse effects*,  therapeutic use
Lens, Crystalline / drug effects,  pathology
Metronidazole / adverse effects*,  therapeutic use
Myopia / chemically induced*,  pathology
Trimethoprim-Sulfamethoxazole Combination / adverse effects*,  therapeutic use
Reg. No./Substance:
443-48-1/Metronidazole; 58-93-5/Hydrochlorothiazide; 8064-90-2/Trimethoprim-Sulfamethoxazole Combination

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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