Document Detail

Drug-induced methaemoglobinaemia following elective coronary artery bypass grafting.
MedLine Citation:
PMID:  17567353     Owner:  NLM     Status:  MEDLINE    
Dapsone can alter the oxygen carrying capacity of haemoglobin. Some patients are more susceptible to these effects because of genetic factors, comorbidities or peri-operative factors such as anaemia. We present a 57-year-old lady who underwent elective coronary artery bypass grafting. Deterioration in neurological and respiratory condition prompted a review of her drug treatment. A combination of long-term dapsone therapy, co-existing cardiac and respiratory disease, postoperative anaemia and renal impairment contributed to her decompensation, despite a relatively low level of methaemoglobin. Successful management included stopping dapsone therapy, supportive care and administration of ascorbic acid.
A Choi; A Sarang
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Anaesthesia     Volume:  62     ISSN:  0003-2409     ISO Abbreviation:  Anaesthesia     Publication Date:  2007 Jul 
Date Detail:
Created Date:  2007-06-14     Completed Date:  2007-07-24     Revised Date:  2007-11-27    
Medline Journal Info:
Nlm Unique ID:  0370524     Medline TA:  Anaesthesia     Country:  England    
Other Details:
Languages:  eng     Pagination:  737-40     Citation Subset:  AIM; IM    
Broomfield Hospital, Chelmsford CM1 7ET, UK.
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MeSH Terms
Anti-Inflammatory Agents, Non-Steroidal / adverse effects*
Antioxidants / therapeutic use
Ascorbic Acid / therapeutic use
Coronary Artery Bypass*
Dapsone / adverse effects*
Hypoxia, Brain / chemically induced
Methemoglobinemia / chemically induced*,  drug therapy
Middle Aged
Postoperative Complications*
Reg. No./Substance:
0/Anti-Inflammatory Agents, Non-Steroidal; 0/Antioxidants; 50-81-7/Ascorbic Acid; 80-08-0/Dapsone
Comment In:
Anaesthesia. 2007 Nov;62(11):1188   [PMID:  17924910 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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