Document Detail

Drug induced intracranial hypertension associated with sulphasalazine treatment.
MedLine Citation:
PMID:  18070060     Owner:  NLM     Status:  MEDLINE    
A 25-year-old female patient developed headache and papilledema under sulphasalazine treatment for ulcerative colitis. The patient met the International Headache Society's criteria for idiopathic intracranial hypertension. Sulphasalazine was discontinued and the patient was given azathioprine for ulcerative colitis and acetazolamide for intracranial hypertension. Three weeks later, her examination was normal and lumbar puncture revealed an opening pressure of 180-mm H(2)O. Sulphasalazine is a product of 5 aminosalicylate (5 ASA) and there seems to be a relationship between the administration of sulphasalazine and the onset of intracranial hypertension symptoms. Early diagnosis of intracranial hypertension is important in patients with ulcerative colitis receiving 5 ASA treatment to prevent visual complications.
Eser Sevgi; Gul Yalcin; Tulay Kansu; Kubilay Varli
Publication Detail:
Type:  Case Reports; Journal Article     Date:  2007-12-07
Journal Detail:
Title:  Headache     Volume:  48     ISSN:  0017-8748     ISO Abbreviation:  Headache     Publication Date:  2008 Feb 
Date Detail:
Created Date:  2008-01-31     Completed Date:  2008-06-13     Revised Date:  2009-02-02    
Medline Journal Info:
Nlm Unique ID:  2985091R     Medline TA:  Headache     Country:  United States    
Other Details:
Languages:  eng     Pagination:  296-8     Citation Subset:  IM    
Hacettepe University Faculty of Medicine, Department of Neurology, Ankara, Turkey.
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MeSH Terms
Anti-Inflammatory Agents, Non-Steroidal / adverse effects*
Colitis, Ulcerative / drug therapy
Headache / chemically induced
Intracranial Hypertension / chemically induced*,  diagnosis
Sulfasalazine / adverse effects*
Reg. No./Substance:
0/Anti-Inflammatory Agents, Non-Steroidal; 599-79-1/Sulfasalazine
Comment In:
Headache. 2008 Oct;48(9):1383-4   [PMID:  18647179 ]

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