| Drug-induced hypertension. Recognition and management in older patients. | |
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MedLine Citation:
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PMID: 9303278 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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This article reviews the potential of a number of drug classes to produce or aggravate hypertension, with particular emphasis on older patients. Although little information is available regarding the hypertensive effects of mineralocorticoids in the elderly, glucocorticoids usually induce an increase in blood pressure (BP) that is dosage-dependent. Nonsteroidal anti-inflammatory drugs occasionally increase BP, but this effect is not usually clinically relevant. The alleged hypertensive potential of oral antihyperglycaemic agents has not yet been substantiated. In contrast, some antidepressants may be particularly dangerous in terms of their hypertensive complications. Although hypertension may be induced by monoamine oxidase inhibitors (MAOIs) given as monotherapy, severe hypertension is more likely to occur when MAOIs are combined with other sympathomimetic drugs. Several other drugs may also increase the risk of hypertension in elderly patients, but reliable data are lacking for most of these agents. Elderly people who are being treated with drugs that may increase BP should be closely monitored. This is particularly true for drugs that act on the CNS. |
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Authors:
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P W de Leeuw |
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Publication Detail:
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Type: Comparative Study; Journal Article; Review |
Journal Detail:
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Title: Drugs & aging Volume: 11 ISSN: 1170-229X ISO Abbreviation: Drugs Aging Publication Date: 1997 Sep |
Date Detail:
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Created Date: 1997-12-17 Completed Date: 1997-12-17 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9102074 Medline TA: Drugs Aging Country: NEW ZEALAND |
Other Details:
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Languages: eng Pagination: 178-85 Citation Subset: IM |
Affiliation:
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Department of Medicine, University Hospital Maastricht, The Netherlands. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adrenal Cortex Hormones
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adverse effects Aged Anti-Inflammatory Agents, Non-Steroidal / adverse effects Antidepressive Agents / adverse effects Blood Pressure / drug effects* Humans Hypertension / chemically induced*, diagnosis, therapy Hypoglycemic Agents / adverse effects Middle Aged Retrospective Studies |
| Chemical | |
Reg. No./Substance:
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0/Adrenal Cortex Hormones; 0/Anti-Inflammatory Agents, Non-Steroidal; 0/Antidepressive Agents; 0/Hypoglycemic Agents |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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