Document Detail

Drug-induced hypertension. Recognition and management in older patients.
MedLine Citation:
PMID:  9303278     Owner:  NLM     Status:  MEDLINE    
This article reviews the potential of a number of drug classes to produce or aggravate hypertension, with particular emphasis on older patients. Although little information is available regarding the hypertensive effects of mineralocorticoids in the elderly, glucocorticoids usually induce an increase in blood pressure (BP) that is dosage-dependent. Nonsteroidal anti-inflammatory drugs occasionally increase BP, but this effect is not usually clinically relevant. The alleged hypertensive potential of oral antihyperglycaemic agents has not yet been substantiated. In contrast, some antidepressants may be particularly dangerous in terms of their hypertensive complications. Although hypertension may be induced by monoamine oxidase inhibitors (MAOIs) given as monotherapy, severe hypertension is more likely to occur when MAOIs are combined with other sympathomimetic drugs. Several other drugs may also increase the risk of hypertension in elderly patients, but reliable data are lacking for most of these agents. Elderly people who are being treated with drugs that may increase BP should be closely monitored. This is particularly true for drugs that act on the CNS.
P W de Leeuw
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Publication Detail:
Type:  Comparative Study; Journal Article; Review    
Journal Detail:
Title:  Drugs & aging     Volume:  11     ISSN:  1170-229X     ISO Abbreviation:  Drugs Aging     Publication Date:  1997 Sep 
Date Detail:
Created Date:  1997-12-17     Completed Date:  1997-12-17     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9102074     Medline TA:  Drugs Aging     Country:  NEW ZEALAND    
Other Details:
Languages:  eng     Pagination:  178-85     Citation Subset:  IM    
Department of Medicine, University Hospital Maastricht, The Netherlands.
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MeSH Terms
Adrenal Cortex Hormones / adverse effects
Anti-Inflammatory Agents, Non-Steroidal / adverse effects
Antidepressive Agents / adverse effects
Blood Pressure / drug effects*
Hypertension / chemically induced*,  diagnosis,  therapy
Hypoglycemic Agents / adverse effects
Middle Aged
Retrospective Studies
Reg. No./Substance:
0/Adrenal Cortex Hormones; 0/Anti-Inflammatory Agents, Non-Steroidal; 0/Antidepressive Agents; 0/Hypoglycemic Agents

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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