| Drug-induced alterations in tumour perfusion yield increases in tumour cell radiosensitivity. | |
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MedLine Citation:
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PMID: 11720448 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The perfusion of human tumour xenografts was manipulated by administration of diltiazem and pentoxifylline, and the extent that observed changes in tumour perfusion altered tumour radiosensitivity was determined. 2 tumour systems having intrinsically different types of hypoxia were studied. The responses of SiHa tumours, which have essentially no transient hypoxia, were compared to the responses of WiDr tumours, which contain chronically and transiently hypoxic cells. We found that relatively modest increases in net tumour perfusion increased tumour cell radiosensitivity in WiDr tumours to a greater extent than in SiHa tumours. Moreover, redistribution of blood flow within WiDr tumours was observed on a micro-regional level that was largely independent of changes in net tumour perfusion. Through fluorescence-activated cell sorting coupled with an in vivo-in vitro cloning assay, increases in the radiosensitivity of WiDr tumour cells at intermediate levels of oxygenation were observed, consistent with the expectation that a redistribution of tumour blood flow had increased oxygen delivery to transiently hypoxic tumour cells. Our data therefore suggest that drug-induced changes in tumour micro-perfusion can alter the radiosensitivity of transiently hypoxic tumour cells, and that increasing the radiosensitivity of tumour cells at intermediate levels of oxygenation is therapeutically relevant. |
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Authors:
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K L Bennewith; R E Durand |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: British journal of cancer Volume: 85 ISSN: 0007-0920 ISO Abbreviation: Br. J. Cancer Publication Date: 2001 Nov |
Date Detail:
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Created Date: 2001-11-26 Completed Date: 2002-02-14 Revised Date: 2010-09-14 |
Medline Journal Info:
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Nlm Unique ID: 0370635 Medline TA: Br J Cancer Country: Scotland |
Other Details:
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Languages: eng Pagination: 1577-84 Citation Subset: IM |
Affiliation:
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Medical Biophysics Department, British Columbia Cancer Research Centre, 601 West 10th Avenue, Vancouver, B.C., Canada V5Z 1L3. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Calcium Channel Blockers / pharmacology* Diltiazem / pharmacology* Dose-Response Relationship, Drug Flow Cytometry Hematologic Agents / pharmacology* Humans Kinetics Mice Neoplasms / blood, radiotherapy* Pentoxifylline / pharmacology* Perfusion Radiation Tolerance* Regional Blood Flow Rubidium Radioisotopes / administration & dosage Tumor Cells, Cultured Xenograft Model Antitumor Assays |
| Chemical | |
Reg. No./Substance:
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0/Calcium Channel Blockers; 0/Hematologic Agents; 0/Rubidium Radioisotopes; 42399-41-7/Diltiazem; 6493-05-6/Pentoxifylline |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
| Full Text | |
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Journal Information Journal ID (nlm-ta): Br J Cancer ISSN: 0007-0920 ISSN: 1532-1827 Publisher: Nature Publishing Group |
Article Information Download PDF  Copyright 2001, Cancer Research Campaign Received Day: 11 Month: 12 Year: 2000 Revision Received Day: 17 Month: 07 Year: 2001 Accepted Day: 19 Month: 07 Year: 2001 Print publication date: Month: 11 Year: 2001 Volume: 85 Issue: 10 First Page: 1577 Last Page: 1584 ID: 2363939 Publisher Item Identifier: 6692123 DOI: 10.1054/bjoc.2001.2123 PubMed Id: 11720448 |
| Drug-induced alterations in tumour perfusion yield increases in tumour cell radiosensitivity | |
| K L Bennewith1 | |
| R E Durand1 | |
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1Medical Biophysics Department, British Columbia Cancer Research Centre, 601 West 10th Avenue, Vancouver, V5Z 1L3, Canada |
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Article Categories:
Keywords: hypoxia, tumour perfusion, radiosensitivity, pentoxifylline, diltiazem. |
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