| Drug-induced acute liver disease. | |
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MedLine Citation:
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PMID: 2608576 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Fifty-three patients with drug-induced acute liver disease are reported. There were 35 females and 18 males with a mean age of 41 years. All but one patient had jaundice or hyperbilirubinaemia and 51 had abnormal liver enzymes. Histologically 38 patients (72%) had cholestatic injury while 15 had cytotoxic parenchymal damage. Methyldopa, chlorpropamide, chlorpromazine, halothane and the contraceptive pill accounted for 60% of cases. Fifty-one patients recovered after drug withdrawal while 2 died of hepatic failure. Drug-induced liver injury must be considered in patients presenting with evidence of hepatic disease as the majority will recover on withdrawal. |
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Authors:
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M G Lee; B Hanchard; N P Williams |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Postgraduate medical journal Volume: 65 ISSN: 0032-5473 ISO Abbreviation: Postgrad Med J Publication Date: 1989 Jun |
Date Detail:
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Created Date: 1990-02-12 Completed Date: 1990-02-12 Revised Date: 2009-11-19 |
Medline Journal Info:
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Nlm Unique ID: 0234135 Medline TA: Postgrad Med J Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 367-70 Citation Subset: IM |
Affiliation:
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Department of Medicine, University Hospital, University of the West Indies, Kingston, Jamaica. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Acute Disease Adolescent Adult Age Factors Aged Aged, 80 and over Drug-Induced Liver Injury* Female Humans Liver Diseases / pathology Male Middle Aged Sex Factors |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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