| Drug-induced Lyell and Stevens-Johnson syndromes. | |
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MedLine Citation:
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PMID: 19391288 Owner: HSR Status: MEDLINE |
Abstract/OtherAbstract:
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1) Lyell syndrome is characterised by toxic epidermal necrolysis in which epidermal detachment affects more than 30% of the body surface area. Stevens-Johnson syndrome is a minor form affecting less than 10% of the body surface area; 2) Patients who present with these cutaneous symptoms, along with throat pain, red eyes and a damaged or detached oral mucosa must be hospitalised immediately; 3) Lyell syndrome is exclusively caused by drugs while Stevens-Johnson syndrome can also be caused by bacteria and viruses. Rapid withdrawal of the drug improves prognosis. |
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Authors:
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- |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Prescrire international Volume: 18 ISSN: 1167-7422 ISO Abbreviation: Prescrire Int Publication Date: 2009 Feb |
Date Detail:
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Created Date: 2009-04-24 Completed Date: 2009-04-28 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9439295 Medline TA: Prescrire Int Country: France |
Other Details:
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Languages: eng Pagination: 20-2 Citation Subset: T |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Allopurinol
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adverse effects* Anti-Infective Agents / adverse effects* Anti-Inflammatory Agents / adverse effects* Anticonvulsants / adverse effects* Epidermal Necrolysis, Toxic* / complications, drug therapy, etiology, pathology Erythema Multiforme* / complications, drug therapy, etiology, pathology Humans Stevens-Johnson Syndrome* / complications, drug therapy, etiology, pathology Sulfonamides / adverse effects* Trimethoprim-Sulfamethoxazole Combination / adverse effects* |
| Chemical | |
Reg. No./Substance:
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0/Anti-Infective Agents; 0/Anti-Inflammatory Agents; 0/Anticonvulsants; 0/Sulfonamides; 315-30-0/Allopurinol; 8064-90-2/Trimethoprim-Sulfamethoxazole Combination |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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